Acute respiratory distress syndrome or why is she dead?

Research output: Contribution to journalReview articlepeer-review


Comprehensive books and book chapters describe the acute respiratory distress syndrome (ARDS). A MEDLINE search (1966 to present) with the MESH term 'respiratory distress syndrome, adult' plus the publication type as 'review,' yields 1,089 citations. So, why read another review? I approach ARDS with, at least, biases that a) the mortality rate from ARDS fell (or is failing) compared with a decade ago; b) lung protective strategies and the associated concept of permissive hypercapnia are, in part, responsible for the decreased mortality rate; c) careful analysis of current practice, if well codified, will allow complex pattern recognition upon which iterative changes can be made and analyzed; and d) single-intervention clinical trials, again demanding nearly unprecedented standardization, will be less useful than multimodality interventions.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalNew Horizons: Science and Practice of Acute Medicine
Issue number3
StatePublished - Nov 17 1999


  • Acute respiratory distress syndrome
  • Clinical trials
  • Data mining
  • Gene therapy
  • Lazaroids
  • Retinoids

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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