Acute renal failure in hematopoietic cell transplantation

C. R. Parikh, S. G. Coca

Research output: Contribution to journalShort surveypeer-review

Abstract

Hematopoietic cell transplantation is a common procedure for the treatment of malignancies and some non-malignant hematologic disorders. In addition to other transplant-related organ toxicities, acute renal failure is a common complication following transplantation. This review discusses the incidence, timing, etiologies, risk factors, and prognosis of renal failure associated with three commonly used transplantation procedures - myeloablative autologous, myeloablative allogeneic, and non-myeloablative allogeneic transplantation. It is important to note that the epidemiology and prognosis of renal failure are distinct with these three transplantation procedures. However, the common theme is that mortality increases with worsening renal failure with all three procedures. Moreover, mortality is >80% for patients with renal failure requiring dialysis. It also appears that surviving patients have an increased risk of chronic kidney disease after renal failure. The reduction of acute renal failure will have several advantages, including reducing mortality and the burden of chronic kidney disease following transplantation.

Original languageEnglish (US)
Pages (from-to)430-435
Number of pages6
JournalKidney international
Volume69
Issue number3
DOIs
StatePublished - Feb 2006
Externally publishedYes

Keywords

  • Allogeneic
  • Autologous
  • Chronic kidney disease
  • Hepatic veno-occlusive disease
  • Non-myeloablative allogeneic
  • Thrombotic microangiopathy

ASJC Scopus subject areas

  • Nephrology

Fingerprint

Dive into the research topics of 'Acute renal failure in hematopoietic cell transplantation'. Together they form a unique fingerprint.

Cite this