TY - JOUR
T1 - Acute renal failure in hematopoietic cell transplantation
AU - Parikh, C. R.
AU - Coca, S. G.
N1 - Funding Information:
We thank the investigators at the FHCRC for their collaboration and interest in the studies of renal failure in hematopoietic cell transplantation. Dr Parikh is supported by Grant K23-DK064689 from the National Institutes of Health, National Institute of Diabetes and Digestive Diseases, Bethesda, MD.
PY - 2006/2
Y1 - 2006/2
N2 - Hematopoietic cell transplantation is a common procedure for the treatment of malignancies and some non-malignant hematologic disorders. In addition to other transplant-related organ toxicities, acute renal failure is a common complication following transplantation. This review discusses the incidence, timing, etiologies, risk factors, and prognosis of renal failure associated with three commonly used transplantation procedures - myeloablative autologous, myeloablative allogeneic, and non-myeloablative allogeneic transplantation. It is important to note that the epidemiology and prognosis of renal failure are distinct with these three transplantation procedures. However, the common theme is that mortality increases with worsening renal failure with all three procedures. Moreover, mortality is >80% for patients with renal failure requiring dialysis. It also appears that surviving patients have an increased risk of chronic kidney disease after renal failure. The reduction of acute renal failure will have several advantages, including reducing mortality and the burden of chronic kidney disease following transplantation.
AB - Hematopoietic cell transplantation is a common procedure for the treatment of malignancies and some non-malignant hematologic disorders. In addition to other transplant-related organ toxicities, acute renal failure is a common complication following transplantation. This review discusses the incidence, timing, etiologies, risk factors, and prognosis of renal failure associated with three commonly used transplantation procedures - myeloablative autologous, myeloablative allogeneic, and non-myeloablative allogeneic transplantation. It is important to note that the epidemiology and prognosis of renal failure are distinct with these three transplantation procedures. However, the common theme is that mortality increases with worsening renal failure with all three procedures. Moreover, mortality is >80% for patients with renal failure requiring dialysis. It also appears that surviving patients have an increased risk of chronic kidney disease after renal failure. The reduction of acute renal failure will have several advantages, including reducing mortality and the burden of chronic kidney disease following transplantation.
KW - Allogeneic
KW - Autologous
KW - Chronic kidney disease
KW - Hepatic veno-occlusive disease
KW - Non-myeloablative allogeneic
KW - Thrombotic microangiopathy
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U2 - 10.1038/sj.ki.5000055
DO - 10.1038/sj.ki.5000055
M3 - Short survey
C2 - 16395267
AN - SCOPUS:31544461541
SN - 0085-2538
VL - 69
SP - 430
EP - 435
JO - Kidney international
JF - Kidney international
IS - 3
ER -