Acute renal allograft rejection with severe tubulitis (Banff 1997 grade Ib)

Marta Ida Minervini, Michael Torbenson, Velma Scantlebury, Carlos Vivas, Mark Jordan, Ron Shapiro, Parmjeet S. Randhawa

Research output: Contribution to journalArticle

Abstract

Recent studies have correlated renal allograft function with individual histologic lesions defined in the Banff schema of kidney transplantation pathology. The clinical significance of severe tubulitis (Banff 97 grade t3) has not been specifically examined. We compared the clinical course and response to antirejection therapy in 36 patients with t3 tubulitis, and 137 patients with milder grades of tubulitis and varying grades of intimal arteritis. Rejection associated with severe tubulitis (grade t3) was associated with graft outcome that was worse than mild to moderate tubulitis (grades t1 or t2) and approached that seen in grade v1 intimal arteritis. Rejection characterized by grade v2 or v3 intimal arteritis had worse prognosis than v1 intimal arteritis and all grades of tubulitis without coexisting intimal arteritis. These observations validate the Banff 97 recommendation that the severity of both tubulitis and intimal arteritis needs to be graded in renal allograft biopsies. In addition, grade t3 tubulitis is identified as a lesion which should be a cause for clinical concern.

Original languageEnglish (US)
Pages (from-to)553-558
Number of pages6
JournalAmerican Journal of Surgical Pathology
Volume24
Issue number4
DOIs
StatePublished - Apr 2000
Externally publishedYes

Fingerprint

Tunica Intima
Arteritis
Allografts
Kidney
Kidney Transplantation
Immunosuppression
Pathology
Transplants
Biopsy

Keywords

  • Allograft
  • Banff
  • Intimal arteritis
  • Pathology
  • Rejection
  • Renal transplantation
  • Severe tubulitis

ASJC Scopus subject areas

  • Anatomy
  • Pathology and Forensic Medicine

Cite this

Minervini, M. I., Torbenson, M., Scantlebury, V., Vivas, C., Jordan, M., Shapiro, R., & Randhawa, P. S. (2000). Acute renal allograft rejection with severe tubulitis (Banff 1997 grade Ib). American Journal of Surgical Pathology, 24(4), 553-558. https://doi.org/10.1097/00000478-200004000-00009

Acute renal allograft rejection with severe tubulitis (Banff 1997 grade Ib). / Minervini, Marta Ida; Torbenson, Michael; Scantlebury, Velma; Vivas, Carlos; Jordan, Mark; Shapiro, Ron; Randhawa, Parmjeet S.

In: American Journal of Surgical Pathology, Vol. 24, No. 4, 04.2000, p. 553-558.

Research output: Contribution to journalArticle

Minervini, MI, Torbenson, M, Scantlebury, V, Vivas, C, Jordan, M, Shapiro, R & Randhawa, PS 2000, 'Acute renal allograft rejection with severe tubulitis (Banff 1997 grade Ib)', American Journal of Surgical Pathology, vol. 24, no. 4, pp. 553-558. https://doi.org/10.1097/00000478-200004000-00009
Minervini, Marta Ida ; Torbenson, Michael ; Scantlebury, Velma ; Vivas, Carlos ; Jordan, Mark ; Shapiro, Ron ; Randhawa, Parmjeet S. / Acute renal allograft rejection with severe tubulitis (Banff 1997 grade Ib). In: American Journal of Surgical Pathology. 2000 ; Vol. 24, No. 4. pp. 553-558.
@article{c125075e60e34b9eaa678480b5f405cc,
title = "Acute renal allograft rejection with severe tubulitis (Banff 1997 grade Ib)",
abstract = "Recent studies have correlated renal allograft function with individual histologic lesions defined in the Banff schema of kidney transplantation pathology. The clinical significance of severe tubulitis (Banff 97 grade t3) has not been specifically examined. We compared the clinical course and response to antirejection therapy in 36 patients with t3 tubulitis, and 137 patients with milder grades of tubulitis and varying grades of intimal arteritis. Rejection associated with severe tubulitis (grade t3) was associated with graft outcome that was worse than mild to moderate tubulitis (grades t1 or t2) and approached that seen in grade v1 intimal arteritis. Rejection characterized by grade v2 or v3 intimal arteritis had worse prognosis than v1 intimal arteritis and all grades of tubulitis without coexisting intimal arteritis. These observations validate the Banff 97 recommendation that the severity of both tubulitis and intimal arteritis needs to be graded in renal allograft biopsies. In addition, grade t3 tubulitis is identified as a lesion which should be a cause for clinical concern.",
keywords = "Allograft, Banff, Intimal arteritis, Pathology, Rejection, Renal transplantation, Severe tubulitis",
author = "Minervini, {Marta Ida} and Michael Torbenson and Velma Scantlebury and Carlos Vivas and Mark Jordan and Ron Shapiro and Randhawa, {Parmjeet S.}",
year = "2000",
month = "4",
doi = "10.1097/00000478-200004000-00009",
language = "English (US)",
volume = "24",
pages = "553--558",
journal = "American Journal of Surgical Pathology",
issn = "0147-5185",
publisher = "Lippincott Williams and Wilkins",
number = "4",

}

TY - JOUR

T1 - Acute renal allograft rejection with severe tubulitis (Banff 1997 grade Ib)

AU - Minervini, Marta Ida

AU - Torbenson, Michael

AU - Scantlebury, Velma

AU - Vivas, Carlos

AU - Jordan, Mark

AU - Shapiro, Ron

AU - Randhawa, Parmjeet S.

PY - 2000/4

Y1 - 2000/4

N2 - Recent studies have correlated renal allograft function with individual histologic lesions defined in the Banff schema of kidney transplantation pathology. The clinical significance of severe tubulitis (Banff 97 grade t3) has not been specifically examined. We compared the clinical course and response to antirejection therapy in 36 patients with t3 tubulitis, and 137 patients with milder grades of tubulitis and varying grades of intimal arteritis. Rejection associated with severe tubulitis (grade t3) was associated with graft outcome that was worse than mild to moderate tubulitis (grades t1 or t2) and approached that seen in grade v1 intimal arteritis. Rejection characterized by grade v2 or v3 intimal arteritis had worse prognosis than v1 intimal arteritis and all grades of tubulitis without coexisting intimal arteritis. These observations validate the Banff 97 recommendation that the severity of both tubulitis and intimal arteritis needs to be graded in renal allograft biopsies. In addition, grade t3 tubulitis is identified as a lesion which should be a cause for clinical concern.

AB - Recent studies have correlated renal allograft function with individual histologic lesions defined in the Banff schema of kidney transplantation pathology. The clinical significance of severe tubulitis (Banff 97 grade t3) has not been specifically examined. We compared the clinical course and response to antirejection therapy in 36 patients with t3 tubulitis, and 137 patients with milder grades of tubulitis and varying grades of intimal arteritis. Rejection associated with severe tubulitis (grade t3) was associated with graft outcome that was worse than mild to moderate tubulitis (grades t1 or t2) and approached that seen in grade v1 intimal arteritis. Rejection characterized by grade v2 or v3 intimal arteritis had worse prognosis than v1 intimal arteritis and all grades of tubulitis without coexisting intimal arteritis. These observations validate the Banff 97 recommendation that the severity of both tubulitis and intimal arteritis needs to be graded in renal allograft biopsies. In addition, grade t3 tubulitis is identified as a lesion which should be a cause for clinical concern.

KW - Allograft

KW - Banff

KW - Intimal arteritis

KW - Pathology

KW - Rejection

KW - Renal transplantation

KW - Severe tubulitis

UR - http://www.scopus.com/inward/record.url?scp=0034125691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0034125691&partnerID=8YFLogxK

U2 - 10.1097/00000478-200004000-00009

DO - 10.1097/00000478-200004000-00009

M3 - Article

C2 - 10757402

AN - SCOPUS:0034125691

VL - 24

SP - 553

EP - 558

JO - American Journal of Surgical Pathology

JF - American Journal of Surgical Pathology

SN - 0147-5185

IS - 4

ER -