Acute pancreatitis with hyperlipemia. Evidence for a persistent defect in lipid metabolism

John L. Cameron, David M. Capuzzi, George D. Zuidema, Simeon Margolis

Research output: Contribution to journalArticlepeer-review

Abstract

Hyperlipemia has been recognized with increasing frequency in patients with acute pancreatitis. The significance of this association is unknown. Twenty-two such patients were electively readmitted to a metabolic ward for study of their lipid metabolism during a quiescent period. Persistent fasting hypertriglyceridemia was found in 16 and abnormal lipoprotein electrophoretic patterns in 17. In addition, response to a lipid load was abnormal; in 20 of the 22 patients triglyceride levels rose over 500 mg/100 ml, and in 10 over 1,000 mg/100 ml. It is concluded that the lipid abnormalities detected during the acute attack of pancreatitis were not secondary but persisted long after the patient had recovered. Such underlying lipid abnormalities may play an intermediary role in the pathogenesis of pancreatitis.

Original languageEnglish (US)
Pages (from-to)482-487
Number of pages6
JournalThe American journal of medicine
Volume56
Issue number4
DOIs
StatePublished - Apr 1974
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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