Acute pancreatitis: Experimental evaluation of steroid, albumin and Trasylol therapy

Taizo Kimura, George D. Zuidema, John L. Cameron

Research output: Contribution to journalArticle

Abstract

The efficacy of steroids, albumin and Trasylol administration in the treatment of experimental pancreatitis was evaluated. An isolated, ex vivo, perfused canine pancreas preparation was used and pancreatitis was initiated by free fatty acid infusion. Steroid administration worsened pancreatitis, Trasylol had no effect, and albumin was markedly effective in ameliorating pancreatitis. These results were interpreted as evidence against enzyme extravasation and for capillary injury as the initial step in the pathogenesis of pancreatitis.

Original languageEnglish (US)
Pages (from-to)403-408
Number of pages6
JournalAmerican journal of surgery
Volume140
Issue number3
DOIs
StatePublished - Jan 1 1980

ASJC Scopus subject areas

  • Surgery

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