Acute pancreatitis. Experimental evaluation of steroid, albumin and trasylol therapy

T. Kimura, G. D. Zuidema, John L Cameron

Research output: Contribution to journalArticle

Abstract

The efficacy of steroids, albumin and Trasylol administration in the treatment of experimental pancreatitis was evaluated. An isolated, ex vivo, perfused canine pancreas preparation was used and pancreatitis was initiated by free fatty acid infusion. Steroid administration worsened pancreatritis, Trasylol had no effect, and albumin was markedly effective in ameliorating pancreatitis. These results were interpreted as evidence against enzyme extravasation and for capillary injury as the initial step in the pathogenesis of pancreatitis.

Original languageEnglish (US)
Pages (from-to)403-408
Number of pages6
JournalAmerican Journal of Surgery
Volume140
Issue number3
StatePublished - 1980

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Aprotinin
Pancreatitis
Albumins
Steroids
Therapeutics
Nonesterified Fatty Acids
Canidae
Pancreas
Wounds and Injuries
Enzymes

ASJC Scopus subject areas

  • Surgery

Cite this

Acute pancreatitis. Experimental evaluation of steroid, albumin and trasylol therapy. / Kimura, T.; Zuidema, G. D.; Cameron, John L.

In: American Journal of Surgery, Vol. 140, No. 3, 1980, p. 403-408.

Research output: Contribution to journalArticle

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