Abstract
Acute myeloid leukemia (AML) therapies are rapidly evolving with novel targeted therapies showing high-level responses in a notoriously difficult to treat group of patients–the elderly and unfit. This review will examine the outcomes of older AML patients (>60 years old) with conventional induction strategies, and published literature on risks of pursuit of induction. Low-intensity combination therapy response rates appear to be approaching that of induction regimens, and with lower toxicity, low-intensity therapy likely represents the future standard approach in this age group. Lastly, allogeneic transplant appears to have a role in increasing durable remissions regardless of age and should be considered in patients with limited comorbidities.
Original language | English (US) |
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Pages (from-to) | 274-287 |
Number of pages | 14 |
Journal | Leukemia and Lymphoma |
Volume | 59 |
Issue number | 2 |
DOIs | |
State | Published - Feb 1 2018 |
Keywords
- AML
- elderly
- therapy
ASJC Scopus subject areas
- Hematology
- Oncology
- Cancer Research