Acute Meningoencephalitis in Chronic Human Immunodeficiency Virus (HIV) Infection: Putative Central Nervous System Escape of HIV Replication

Karen A. Wendel, Justin Charles McArthur

Research output: Contribution to journalArticle

Abstract

We describe 3 patients with chronic human immunodeficiency virus (HIV) infection who presented with syndromes compatible with acute meningoencephalitis secondary to HIV; these syndromes were characterized by elevated cerebrospinal spinal fluid (CSF) HIV viral loads and T2-weighted signal abnormalities on magnetic resonance imaging of the brain. After the initiation of or a change in highly active antiretroviral therapy (HAART), each of the patients had significant and rapid improvement in neurologic symptoms and dramatic reductions in CSF HIV viral loads. Although further investigation is needed, these findings suggest that measurement of CSF HIV viral load and treatment with central nervous system-penetrating HAART should be considered for patients with acute neurologic complaints, chronic HIV infection, and no other identifiable cause of neurologic illness.

Original languageEnglish (US)
Pages (from-to)1107-1111
Number of pages5
JournalClinical Infectious Diseases
Volume37
Issue number8
DOIs
StatePublished - Oct 15 2003

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Meningoencephalitis
Virus Diseases
Virus Replication
Central Nervous System
HIV
Viral Load
Cerebrospinal Fluid
Highly Active Antiretroviral Therapy
Nervous System
Neurologic Manifestations
Magnetic Resonance Imaging
Brain

ASJC Scopus subject areas

  • Immunology

Cite this

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abstract = "We describe 3 patients with chronic human immunodeficiency virus (HIV) infection who presented with syndromes compatible with acute meningoencephalitis secondary to HIV; these syndromes were characterized by elevated cerebrospinal spinal fluid (CSF) HIV viral loads and T2-weighted signal abnormalities on magnetic resonance imaging of the brain. After the initiation of or a change in highly active antiretroviral therapy (HAART), each of the patients had significant and rapid improvement in neurologic symptoms and dramatic reductions in CSF HIV viral loads. Although further investigation is needed, these findings suggest that measurement of CSF HIV viral load and treatment with central nervous system-penetrating HAART should be considered for patients with acute neurologic complaints, chronic HIV infection, and no other identifiable cause of neurologic illness.",
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