Acute lung injury after allogeneic stem cell transplantation: Is the lung a target of acute graft-versus-host disease?

K. R. Cooke, G. Yanik

Research output: Contribution to journalShort surveypeer-review

Abstract

Allogeneic hematopoietic stem cell transplantation (SCT) is an important therapeutic option for a number of malignant and nonmalignant conditions but the broader application of this treatment strategy is limited by several side effects. In particular, diffuse lung injury is a major complication of SCT that responds poorly to standard therapeutic approaches and significantly contributes to transplant-related morbidity and mortality. Historically, approximately 50% of all pneumonias seen after SCT have been secondary to infection, but the judicious use of broad-spectrum antimicrobial prophylaxis in recent years has tipped the balance of pulmonary complications from infectious to noninfectious causes. This mini review will discuss the definition, risk factors and pathogeneses of noninfectious lung injury that occurs early after allogeneic. SCT.

Original languageEnglish (US)
Pages (from-to)753-765
Number of pages13
JournalBone marrow transplantation
Volume34
Issue number9
DOIs
StatePublished - Nov 2004
Externally publishedYes

Keywords

  • Acute GVHD
  • Allogeneic SCT
  • Lung injury

ASJC Scopus subject areas

  • Hematology
  • Transplantation

Fingerprint

Dive into the research topics of 'Acute lung injury after allogeneic stem cell transplantation: Is the lung a target of acute graft-versus-host disease?'. Together they form a unique fingerprint.

Cite this