Acute illness is associated with suppression of the growth hormone axis in Zimbabwean infants

Andrew D. Jones, Sandra Rukobo, Bernard Chasekwa, Kuda Mutasa, Robert Ntozini, Mduduzi N N Mbuya, Rebecca J. Stoltzfus, Jean Hawes Humphrey, Andrew J. Prendergast

Research output: Contribution to journalArticle

Abstract

Frequent infections contribute to childhood stunting in developing countries but the causal pathways are uncertain. We tested the hypothesis that intercurrent illnesses suppress the growth hormone axis through reductions in insulin-like growth factor 1 (IGF-1). In a birth cohort of 202 HIV-unexposed Zimbabwean infants, we analyzed data on 7-day illness recall and measured plasma interleukin-6, C-reactive protein, alpha-1-acid glycoprotein, and IGF-1 by enzyme-linked immunosorbent assay, at age 6 weeks, and then 3, 6, 12, and 18 months. Children with recent acute illness had lower IGF-1 concentrations than healthy children and IGF-1 correlated inversely (P <0.05) with inflammatory biomarkers at most time points between 3 and 18 months. Using path analysis, we showed that cough and fever had a predominantly indirect effect on suppressing IGF-1, through the acute-phase response, whereas diarrhea had a predominantly direct effect on IGF-1. Acute illness may therefore impact the growth hormone axis through both direct and indirect pathways.

Original languageEnglish (US)
Pages (from-to)463-470
Number of pages8
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume92
Issue number2
DOIs
StatePublished - Feb 1 2015
Externally publishedYes

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Somatomedins
Growth Hormone
Growth Disorders
Orosomucoid
Sick Leave
Acute-Phase Reaction
Cough
C-Reactive Protein
Developing Countries
Diarrhea
Interleukin-6
Fever
Biomarkers
Enzyme-Linked Immunosorbent Assay
HIV
Parturition
Infection

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Jones, A. D., Rukobo, S., Chasekwa, B., Mutasa, K., Ntozini, R., Mbuya, M. N. N., ... Prendergast, A. J. (2015). Acute illness is associated with suppression of the growth hormone axis in Zimbabwean infants. American Journal of Tropical Medicine and Hygiene, 92(2), 463-470. https://doi.org/10.4269/ajtmh.14-0448

Acute illness is associated with suppression of the growth hormone axis in Zimbabwean infants. / Jones, Andrew D.; Rukobo, Sandra; Chasekwa, Bernard; Mutasa, Kuda; Ntozini, Robert; Mbuya, Mduduzi N N; Stoltzfus, Rebecca J.; Humphrey, Jean Hawes; Prendergast, Andrew J.

In: American Journal of Tropical Medicine and Hygiene, Vol. 92, No. 2, 01.02.2015, p. 463-470.

Research output: Contribution to journalArticle

Jones, AD, Rukobo, S, Chasekwa, B, Mutasa, K, Ntozini, R, Mbuya, MNN, Stoltzfus, RJ, Humphrey, JH & Prendergast, AJ 2015, 'Acute illness is associated with suppression of the growth hormone axis in Zimbabwean infants', American Journal of Tropical Medicine and Hygiene, vol. 92, no. 2, pp. 463-470. https://doi.org/10.4269/ajtmh.14-0448
Jones, Andrew D. ; Rukobo, Sandra ; Chasekwa, Bernard ; Mutasa, Kuda ; Ntozini, Robert ; Mbuya, Mduduzi N N ; Stoltzfus, Rebecca J. ; Humphrey, Jean Hawes ; Prendergast, Andrew J. / Acute illness is associated with suppression of the growth hormone axis in Zimbabwean infants. In: American Journal of Tropical Medicine and Hygiene. 2015 ; Vol. 92, No. 2. pp. 463-470.
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