Acute graft-versus-host disease in pancreas transplantation: A comparison of two case presentations and a review of the literature

Adam Weinstein, David Dexter, Debra L. KuKuruga, Benjamin Philosophe, John Hess, David Klassen

Research output: Contribution to journalReview articlepeer-review

Abstract

As a complication of solid organ transplantation, acute graft-versus-host disease (GVHD) is most associated with small bowel and liver transplants. We present two cases of acute GVHD following pancreas transplantation. Case 1 was a 27-year-old female who underwent cadaveric pancreas transplant 9 months after a successful live donor kidney transplant. Case 2 was a 38-year-old male who received a simultaneous cadaveric pancreas and live donor kidney transplant. Both patients presented within 30 days of transplant with nonspecific symptoms. Rejection and infection were ruled out. Both subjects had progressive decline in mentation associated with pancytopenia and hyperbilirubinemia. Rash was not present until late in their hospital course. Skin biopsies demonstrated mixed chimerism with pancreas donor DNA diagnostic of GVHD. Acute GVHD is a rare, often fatal, complication of pancreas transplantation, and its presentation appears to differ from acute GVHD associated with stem cell transplantation.

Original languageEnglish (US)
Pages (from-to)127-131
Number of pages5
JournalTransplantation
Volume82
Issue number1
DOIs
StatePublished - Jul 1 2006
Externally publishedYes

Keywords

  • Case report
  • Graft-versus-host disease
  • Mechanism
  • Pancreas transplantation

ASJC Scopus subject areas

  • Transplantation

Fingerprint

Dive into the research topics of 'Acute graft-versus-host disease in pancreas transplantation: A comparison of two case presentations and a review of the literature'. Together they form a unique fingerprint.

Cite this