Abstract
The renal effects of aspirin and acetaminophen are minor. With a major overdose of acetaminophen, uncommonly renal failure may occur that cannot be ascribed to hepatic failure; its mechanism is unknown. Aspirin may cause a transient shedding of renal tubular cells, alterations in urate excretion, inhibition of spironolactone action, and, in certain clinical settings, a reversible decline in renal function manifested as a fall in glomerular filtration that may be accompanied by mild water, sodium, and potassium retention. Active systemic lupus erythematosus, advanced cirrhosis, and chronic renal insufficiency seem to predispose patients to the effects on renal function, and there is direct or indirect evidence in those conditions that prostaglandin synthesis is an important part of the body's attempt to preserve renal blood flow. Study of these effects has provided new insight into the way in which the kidneys may use prostaglandins to preserve renal function when it is threatened.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 343-348 |
| Number of pages | 6 |
| Journal | Archives of Internal Medicine |
| Volume | 141 |
| Issue number | 3 |
| DOIs | |
| State | Published - Feb 23 1981 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Internal Medicine
Cite this
Acute Effects of Aspirin and Acetaminophen on Renal Function. / Plotz, Paul H.; Kimberly, Robert P.
In: Archives of Internal Medicine, Vol. 141, No. 3, 23.02.1981, p. 343-348.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Acute Effects of Aspirin and Acetaminophen on Renal Function
AU - Plotz, Paul H.
AU - Kimberly, Robert P.
PY - 1981/2/23
Y1 - 1981/2/23
N2 - The renal effects of aspirin and acetaminophen are minor. With a major overdose of acetaminophen, uncommonly renal failure may occur that cannot be ascribed to hepatic failure; its mechanism is unknown. Aspirin may cause a transient shedding of renal tubular cells, alterations in urate excretion, inhibition of spironolactone action, and, in certain clinical settings, a reversible decline in renal function manifested as a fall in glomerular filtration that may be accompanied by mild water, sodium, and potassium retention. Active systemic lupus erythematosus, advanced cirrhosis, and chronic renal insufficiency seem to predispose patients to the effects on renal function, and there is direct or indirect evidence in those conditions that prostaglandin synthesis is an important part of the body's attempt to preserve renal blood flow. Study of these effects has provided new insight into the way in which the kidneys may use prostaglandins to preserve renal function when it is threatened.
AB - The renal effects of aspirin and acetaminophen are minor. With a major overdose of acetaminophen, uncommonly renal failure may occur that cannot be ascribed to hepatic failure; its mechanism is unknown. Aspirin may cause a transient shedding of renal tubular cells, alterations in urate excretion, inhibition of spironolactone action, and, in certain clinical settings, a reversible decline in renal function manifested as a fall in glomerular filtration that may be accompanied by mild water, sodium, and potassium retention. Active systemic lupus erythematosus, advanced cirrhosis, and chronic renal insufficiency seem to predispose patients to the effects on renal function, and there is direct or indirect evidence in those conditions that prostaglandin synthesis is an important part of the body's attempt to preserve renal blood flow. Study of these effects has provided new insight into the way in which the kidneys may use prostaglandins to preserve renal function when it is threatened.
UR - http://www.scopus.com/inward/record.url?scp=0019500988&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019500988&partnerID=8YFLogxK
U2 - 10.1001/archinte.1981.00340030075014
DO - 10.1001/archinte.1981.00340030075014
M3 - Article
C2 - 7008735
AN - SCOPUS:0019500988
VL - 141
SP - 343
EP - 348
JO - JAMA Internal Medicine
JF - JAMA Internal Medicine
SN - 2168-6106
IS - 3
ER -