Five of 24 (21%) normal men (volunteers) administered α-methyl-para-tyrosine (AMPT), a catecholamine-depleting agent, developed acute dystonic reactions. The finding that catecholamine depletion without receptor blockade is sufficient to cause acute dystonia suggests that a variety of neurotransmitter imbalances may lead to idiopathic primary dystonia.
- α-Methyl-para-tyrosine (AMPT)
ASJC Scopus subject areas
- Clinical Neurology
- Pharmacology (medical)