Acute dystonic reaction in normal humans caused by catecholamine depletion

U. D. McCann; D. M. Penetar; G. Belenky

doi:10.1097/00002826-199012000-00009

Acute dystonic reaction in normal humans caused by catecholamine depletion

U. D. McCann, D. M. Penetar, G. Belenky

Research output: Contribution to journal › Article › peer-review

20 Scopus citations

Abstract

Five of 24 (21%) normal men (volunteers) administered α-methyl-para-tyrosine (AMPT), a catecholamine-depleting agent, developed acute dystonic reactions. The finding that catecholamine depletion without receptor blockade is sufficient to cause acute dystonia suggests that a variety of neurotransmitter imbalances may lead to idiopathic primary dystonia.

Original language	English (US)
Pages (from-to)	565-568
Number of pages	4
Journal	Clinical neuropharmacology
Volume	13
Issue number	6
DOIs	https://doi.org/10.1097/00002826-199012000-00009
State	Published - Jan 1 1990
Externally published	Yes

Keywords

Acetylcholine
Dopamine
Dystonia
α-Methyl-para-tyrosine (AMPT)

ASJC Scopus subject areas

Pharmacology
Clinical Neurology
Pharmacology (medical)

Access to Document

10.1097/00002826-199012000-00009

Cite this

@article{b9c1ac0589e84ae882aa1d5dfbff7b69,

title = "Acute dystonic reaction in normal humans caused by catecholamine depletion",

abstract = "Five of 24 (21%) normal men (volunteers) administered α-methyl-para-tyrosine (AMPT), a catecholamine-depleting agent, developed acute dystonic reactions. The finding that catecholamine depletion without receptor blockade is sufficient to cause acute dystonia suggests that a variety of neurotransmitter imbalances may lead to idiopathic primary dystonia.",

keywords = "Acetylcholine, Dopamine, Dystonia, α-Methyl-para-tyrosine (AMPT)",

author = "McCann, {U. D.} and Penetar, {D. M.} and G. Belenky",

year = "1990",

month = jan,

day = "1",

doi = "10.1097/00002826-199012000-00009",

language = "English (US)",

volume = "13",

pages = "565--568",

journal = "Clinical Neuropharmacology",

issn = "0362-5664",

publisher = "Lippincott Williams and Wilkins",

number = "6",

}

TY - JOUR

T1 - Acute dystonic reaction in normal humans caused by catecholamine depletion

AU - McCann, U. D.

AU - Penetar, D. M.

AU - Belenky, G.

PY - 1990/1/1

Y1 - 1990/1/1

N2 - Five of 24 (21%) normal men (volunteers) administered α-methyl-para-tyrosine (AMPT), a catecholamine-depleting agent, developed acute dystonic reactions. The finding that catecholamine depletion without receptor blockade is sufficient to cause acute dystonia suggests that a variety of neurotransmitter imbalances may lead to idiopathic primary dystonia.

AB - Five of 24 (21%) normal men (volunteers) administered α-methyl-para-tyrosine (AMPT), a catecholamine-depleting agent, developed acute dystonic reactions. The finding that catecholamine depletion without receptor blockade is sufficient to cause acute dystonia suggests that a variety of neurotransmitter imbalances may lead to idiopathic primary dystonia.

KW - Acetylcholine

KW - Dopamine

KW - Dystonia

KW - α-Methyl-para-tyrosine (AMPT)

UR - http://www.scopus.com/inward/record.url?scp=0025661943&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025661943&partnerID=8YFLogxK

U2 - 10.1097/00002826-199012000-00009

DO - 10.1097/00002826-199012000-00009

M3 - Article

C2 - 1980430

AN - SCOPUS:0025661943

SN - 0362-5664

VL - 13

SP - 565

EP - 568

JO - Clinical Neuropharmacology

JF - Clinical Neuropharmacology

IS - 6

ER -

Acute dystonic reaction in normal humans caused by catecholamine depletion

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this