Acute dystonic reaction in normal humans caused by catecholamine depletion

U. D. McCann, D. M. Penetar, G. Belenky

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


Five of 24 (21%) normal men (volunteers) administered α-methyl-para-tyrosine (AMPT), a catecholamine-depleting agent, developed acute dystonic reactions. The finding that catecholamine depletion without receptor blockade is sufficient to cause acute dystonia suggests that a variety of neurotransmitter imbalances may lead to idiopathic primary dystonia.

Original languageEnglish (US)
Pages (from-to)565-568
Number of pages4
JournalClinical neuropharmacology
Issue number6
StatePublished - Jan 1 1990
Externally publishedYes


  • Acetylcholine
  • Dopamine
  • Dystonia
  • α-Methyl-para-tyrosine (AMPT)

ASJC Scopus subject areas

  • Pharmacology
  • Clinical Neurology
  • Pharmacology (medical)


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