Acute disseminated encephalomyelitis in China, Singapore and Japan: A comparison with the USA

D. L H Koelman, D. C. Benkeser, Y. Xu, S. X. Neo, K. Tan, M. Katsuno, G. Sobue, J. Natsume, S. Chahin, S. S. Mar, Arun Venkatesan, T. Chitnis, G. M. Hoganson, A. K. Yeshokumar, P. Barreras, B. Majmudar, M. Carone, F. J. Mateen

Research output: Contribution to journalArticle

Abstract

Background and purpose: Ethnicity-related differences in the incidence of acute disseminated encephalomyelitis (ADEM) and other demyelinating diseases including multiple sclerosis and neuromyelitis optica spectrum disorders have been reported. Little is reported on the influence of ethnicity and geographical location in ADEM. Methods: Medical records of patients who presented with ADEM (ICD-9 323.61 and 323.81) at large referral hospitals in China, Singapore and Japan (years 1992-2015) were retrospectively reviewed and data were collected in a centralized database. Presenting features and outcomes of ADEM were compared between this multi-country Asian cohort and a uniformly collected US cohort using risk differences and risk ratios. Both cohorts were standardized to a 35% pediatric population to facilitate the comparison. Results: There were 83 Asian patients (48 male, 16 pediatric) followed for a median of 2 (25th-75th percentile 1-10) months. Asian patients exhibited a 26% higher prevalence of spinal cord involvement on magnetic resonance imaging [95% confidence interval (CI) 0-52%; P = 0.05; 63% vs. 37%], a 39% lower prevalence of preceding events (95% CI 12-65%; P < 0.01; 33% vs. 72%) and a 23% lower prevalence of corpus callosum involvement (95% CI 7-39%; P < 0.01; 8% vs. 31%). No difference was observed between the two cohorts in the probability of relapse over the first year after disease onset. Conclusions: It is hypothesized that the high proportion of Asian patients with spinal cord lesions relates to genetic vulnerability or the higher incidence of neuromyelitis optica spectrum disorders in Asia or could be a spurious association. ADEM presentations most probably vary across geographical settings or ethnicities.

Original languageEnglish (US)
JournalEuropean Journal of Neurology
DOIs
StateAccepted/In press - 2016

Fingerprint

Acute Disseminated Encephalomyelitis
Singapore
China
Japan
Neuromyelitis Optica
Confidence Intervals
Spinal Cord
Pediatrics
Corpus Callosum
Incidence
Demyelinating Diseases
International Classification of Diseases
Multiple Sclerosis
Medical Records
Referral and Consultation
Odds Ratio
Magnetic Resonance Imaging
Databases
Recurrence
Population

Keywords

  • Acute disseminated encephalomyelitis
  • Cohort studies
  • Demyelination
  • International comparison
  • Multiple sclerosis
  • Neuromyelitis optica spectrum disorders

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Koelman, D. L. H., Benkeser, D. C., Xu, Y., Neo, S. X., Tan, K., Katsuno, M., ... Mateen, F. J. (Accepted/In press). Acute disseminated encephalomyelitis in China, Singapore and Japan: A comparison with the USA. European Journal of Neurology. https://doi.org/10.1111/ene.13220

Acute disseminated encephalomyelitis in China, Singapore and Japan : A comparison with the USA. / Koelman, D. L H; Benkeser, D. C.; Xu, Y.; Neo, S. X.; Tan, K.; Katsuno, M.; Sobue, G.; Natsume, J.; Chahin, S.; Mar, S. S.; Venkatesan, Arun; Chitnis, T.; Hoganson, G. M.; Yeshokumar, A. K.; Barreras, P.; Majmudar, B.; Carone, M.; Mateen, F. J.

In: European Journal of Neurology, 2016.

Research output: Contribution to journalArticle

Koelman, DLH, Benkeser, DC, Xu, Y, Neo, SX, Tan, K, Katsuno, M, Sobue, G, Natsume, J, Chahin, S, Mar, SS, Venkatesan, A, Chitnis, T, Hoganson, GM, Yeshokumar, AK, Barreras, P, Majmudar, B, Carone, M & Mateen, FJ 2016, 'Acute disseminated encephalomyelitis in China, Singapore and Japan: A comparison with the USA', European Journal of Neurology. https://doi.org/10.1111/ene.13220
Koelman, D. L H ; Benkeser, D. C. ; Xu, Y. ; Neo, S. X. ; Tan, K. ; Katsuno, M. ; Sobue, G. ; Natsume, J. ; Chahin, S. ; Mar, S. S. ; Venkatesan, Arun ; Chitnis, T. ; Hoganson, G. M. ; Yeshokumar, A. K. ; Barreras, P. ; Majmudar, B. ; Carone, M. ; Mateen, F. J. / Acute disseminated encephalomyelitis in China, Singapore and Japan : A comparison with the USA. In: European Journal of Neurology. 2016.
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title = "Acute disseminated encephalomyelitis in China, Singapore and Japan: A comparison with the USA",
abstract = "Background and purpose: Ethnicity-related differences in the incidence of acute disseminated encephalomyelitis (ADEM) and other demyelinating diseases including multiple sclerosis and neuromyelitis optica spectrum disorders have been reported. Little is reported on the influence of ethnicity and geographical location in ADEM. Methods: Medical records of patients who presented with ADEM (ICD-9 323.61 and 323.81) at large referral hospitals in China, Singapore and Japan (years 1992-2015) were retrospectively reviewed and data were collected in a centralized database. Presenting features and outcomes of ADEM were compared between this multi-country Asian cohort and a uniformly collected US cohort using risk differences and risk ratios. Both cohorts were standardized to a 35{\%} pediatric population to facilitate the comparison. Results: There were 83 Asian patients (48 male, 16 pediatric) followed for a median of 2 (25th-75th percentile 1-10) months. Asian patients exhibited a 26{\%} higher prevalence of spinal cord involvement on magnetic resonance imaging [95{\%} confidence interval (CI) 0-52{\%}; P = 0.05; 63{\%} vs. 37{\%}], a 39{\%} lower prevalence of preceding events (95{\%} CI 12-65{\%}; P < 0.01; 33{\%} vs. 72{\%}) and a 23{\%} lower prevalence of corpus callosum involvement (95{\%} CI 7-39{\%}; P < 0.01; 8{\%} vs. 31{\%}). No difference was observed between the two cohorts in the probability of relapse over the first year after disease onset. Conclusions: It is hypothesized that the high proportion of Asian patients with spinal cord lesions relates to genetic vulnerability or the higher incidence of neuromyelitis optica spectrum disorders in Asia or could be a spurious association. ADEM presentations most probably vary across geographical settings or ethnicities.",
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T1 - Acute disseminated encephalomyelitis in China, Singapore and Japan

T2 - A comparison with the USA

AU - Koelman, D. L H

AU - Benkeser, D. C.

AU - Xu, Y.

AU - Neo, S. X.

AU - Tan, K.

AU - Katsuno, M.

AU - Sobue, G.

AU - Natsume, J.

AU - Chahin, S.

AU - Mar, S. S.

AU - Venkatesan, Arun

AU - Chitnis, T.

AU - Hoganson, G. M.

AU - Yeshokumar, A. K.

AU - Barreras, P.

AU - Majmudar, B.

AU - Carone, M.

AU - Mateen, F. J.

PY - 2016

Y1 - 2016

N2 - Background and purpose: Ethnicity-related differences in the incidence of acute disseminated encephalomyelitis (ADEM) and other demyelinating diseases including multiple sclerosis and neuromyelitis optica spectrum disorders have been reported. Little is reported on the influence of ethnicity and geographical location in ADEM. Methods: Medical records of patients who presented with ADEM (ICD-9 323.61 and 323.81) at large referral hospitals in China, Singapore and Japan (years 1992-2015) were retrospectively reviewed and data were collected in a centralized database. Presenting features and outcomes of ADEM were compared between this multi-country Asian cohort and a uniformly collected US cohort using risk differences and risk ratios. Both cohorts were standardized to a 35% pediatric population to facilitate the comparison. Results: There were 83 Asian patients (48 male, 16 pediatric) followed for a median of 2 (25th-75th percentile 1-10) months. Asian patients exhibited a 26% higher prevalence of spinal cord involvement on magnetic resonance imaging [95% confidence interval (CI) 0-52%; P = 0.05; 63% vs. 37%], a 39% lower prevalence of preceding events (95% CI 12-65%; P < 0.01; 33% vs. 72%) and a 23% lower prevalence of corpus callosum involvement (95% CI 7-39%; P < 0.01; 8% vs. 31%). No difference was observed between the two cohorts in the probability of relapse over the first year after disease onset. Conclusions: It is hypothesized that the high proportion of Asian patients with spinal cord lesions relates to genetic vulnerability or the higher incidence of neuromyelitis optica spectrum disorders in Asia or could be a spurious association. ADEM presentations most probably vary across geographical settings or ethnicities.

AB - Background and purpose: Ethnicity-related differences in the incidence of acute disseminated encephalomyelitis (ADEM) and other demyelinating diseases including multiple sclerosis and neuromyelitis optica spectrum disorders have been reported. Little is reported on the influence of ethnicity and geographical location in ADEM. Methods: Medical records of patients who presented with ADEM (ICD-9 323.61 and 323.81) at large referral hospitals in China, Singapore and Japan (years 1992-2015) were retrospectively reviewed and data were collected in a centralized database. Presenting features and outcomes of ADEM were compared between this multi-country Asian cohort and a uniformly collected US cohort using risk differences and risk ratios. Both cohorts were standardized to a 35% pediatric population to facilitate the comparison. Results: There were 83 Asian patients (48 male, 16 pediatric) followed for a median of 2 (25th-75th percentile 1-10) months. Asian patients exhibited a 26% higher prevalence of spinal cord involvement on magnetic resonance imaging [95% confidence interval (CI) 0-52%; P = 0.05; 63% vs. 37%], a 39% lower prevalence of preceding events (95% CI 12-65%; P < 0.01; 33% vs. 72%) and a 23% lower prevalence of corpus callosum involvement (95% CI 7-39%; P < 0.01; 8% vs. 31%). No difference was observed between the two cohorts in the probability of relapse over the first year after disease onset. Conclusions: It is hypothesized that the high proportion of Asian patients with spinal cord lesions relates to genetic vulnerability or the higher incidence of neuromyelitis optica spectrum disorders in Asia or could be a spurious association. ADEM presentations most probably vary across geographical settings or ethnicities.

KW - Acute disseminated encephalomyelitis

KW - Cohort studies

KW - Demyelination

KW - International comparison

KW - Multiple sclerosis

KW - Neuromyelitis optica spectrum disorders

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