Acute dialysis risk in living kidney donors

Ngan Lam, Anjie Huang, Liane S. Feldman, John S. Gill, Martin Karpinski, Joseph Kim, Scott W. Klarenbach, Greg A. Knoll, Krista L. Lentine, Chris Y. Nguan, Chirag R. Parikh, G. V.Ramesh Prasad, Darin J. Treleaven, Ann Young, Amit X. Garg

Research output: Contribution to journalArticle

Abstract

Background. Reduced kidney function confers a higher risk of acute kidney injury at the time of an inciting event, such as sepsis. Whether the same is true in those with reduced renal mass from living kidney donation is unknown. Methods. We conducted a population-based matched cohort study of all living kidney donors in the province of Ontario, Canada who underwent donor nephrectomy from 1992 to 2009. We manually reviewed the medical records of these living kidney donors and linked this information to provincial health care databases. Non-donors were selected from the healthiest segment of the general population. Results. There were 2027 donors and 20 270 matched non-donors. The median age was 43 years (interquartile range 3450) and individuals were followed for a median of 6.6 years (maximum 17.7 years). The primary outcome was acute dialysis during any hospital stay. Reasons for hospitalization included infectious diseases, cardiovascular diseases and hematological malignancies. Only one donor received acute dialysis in follow-up (6.5 events per 100 000 person-years), a rate which was statistically no different than 14 non-donors (9.4 events per 100 000 person-years). Conclusion. sThese results are reassuring for the practice of living kidney donation. Longer follow-up of this and other donor cohorts will provide more precise estimates about this risk.

Original languageEnglish (US)
Pages (from-to)3291-3295
Number of pages5
JournalNephrology Dialysis Transplantation
Volume27
Issue number8
DOIs
StatePublished - Aug 1 2012

Keywords

  • acute kidney injury
  • administrative health database
  • dialysis
  • living kidney donors

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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    Lam, N., Huang, A., Feldman, L. S., Gill, J. S., Karpinski, M., Kim, J., Klarenbach, S. W., Knoll, G. A., Lentine, K. L., Nguan, C. Y., Parikh, C. R., Prasad, G. V. R., Treleaven, D. J., Young, A., & Garg, A. X. (2012). Acute dialysis risk in living kidney donors. Nephrology Dialysis Transplantation, 27(8), 3291-3295. https://doi.org/10.1093/ndt/gfr802