Acute cortisol reactivity attenuates engagement of fronto-parietal and striatal regions during emotion processing in negative mood disorders

Amy T. Peters, Anna Van Meter, Patrick J. Pruitt, Emily M. Briceño, Kelly A. Ryan, Melissa Hagan, Anne L. Weldon, Michelle T. Kassel, Aaron Vederman, Jon Kar Zubieta, Melvin McInnis, Sara L. Weisenbach, Scott A. Langenecker

    Research output: Contribution to journalArticle

    Abstract

    Objective Depression and bipolar disorder (negative mood disorders, NMD) are associated with dysregulated hypothalamic-pituitary-adrenal (HPA)-axis function and disrupted emotion processing. The neural networks involved in attenuation of HPA-axis reactivity overlap with the circuitry involved in perception and modulation of emotion; however, direct links between these systems are understudied. This study investigated whether cortisol activity prior to undergoing fMRI was related to neural processing of emotional information in participants with NMD. Methods Forty-one adults (Mage = 40.33, SD = 15.57) with major depression (n = 29) or bipolar disorder (n = 12) and 23 healthy control comparisons (Mage = 36.43, SD = 17.33) provided salivary cortisol samples prior to completing a facial emotion perception test during 3-Tesla fMRI. Results Overall, pre-scan cortisol level was positively associated with greater engagement of the dorsal anterior cingulate (dACC), inferior parietal lobule, insula, putamen, precuneus, middle and medial frontal and postcentral gyri, posterior cingulate, and inferior temporal gyrus during emotion processing of all faces. NMD status moderated this effect; in NMD participants’ pre-scan cortisol was associated with attenuated activation of the insula, postcentral gyrus, precuneus, and putamen for fearful faces and the medial frontal gyrus for angry faces relative to HCs. Cortisol-related attenuation of activation among NMD participants was also observed for facial identification in the dACC, putamen, middle temporal gyrus, precuneus, and caudate. Conclusions Across all participants, cortisol was associated with greater activation in several regions involved in the perception and control of emotion. However, cortisol responsivity was associated with hypoactivation of several of these regions in the NMD group, suggesting that HPA-axis activity may selectively interfere with the potentially adaptive recruitment of circuits supporting emotion perception, processing and/or regulation in mood disorders.

    Original languageEnglish (US)
    Pages (from-to)67-78
    Number of pages12
    JournalPsychoneuroendocrinology
    Volume73
    DOIs
    StatePublished - Nov 1 2016

    Keywords

    • Cortisol
    • Depression
    • Emotion processing
    • fMRI

    ASJC Scopus subject areas

    • Endocrinology, Diabetes and Metabolism
    • Endocrinology
    • Endocrine and Autonomic Systems
    • Psychiatry and Mental health
    • Biological Psychiatry

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  • Cite this

    Peters, A. T., Van Meter, A., Pruitt, P. J., Briceño, E. M., Ryan, K. A., Hagan, M., Weldon, A. L., Kassel, M. T., Vederman, A., Zubieta, J. K., McInnis, M., Weisenbach, S. L., & Langenecker, S. A. (2016). Acute cortisol reactivity attenuates engagement of fronto-parietal and striatal regions during emotion processing in negative mood disorders. Psychoneuroendocrinology, 73, 67-78. https://doi.org/10.1016/j.psyneuen.2016.07.215