Acute changes in infranodal conduction time following left ventriculography and sublingual nitroglycerin administration in man

Robert W. Peters, Michael L. Fisher, Steven Resnick, Gary D. Plotnick, Nathan H. Carliner, Melvin M. Scheinman

Research output: Contribution to journalArticle

Abstract

During diagnostic cardiac catheterization for the evaluation of chest pain, His bundle electrograms were obtained in 32 male patients before and 2 to 5 minutes after each of two interventions known to acutely affect left ventricular volume and left ventricular end-diastolic pressure (the injection of 40 to 60 cc of contrast medium during left ventriculography and the administration of 0.4 mg of sublingual nitroglycerin). Changes in left ventricular end-diastolic pressure (18 ± 6 vs 30 ± 7 mm Hg, p <0.001 following ventriculography and 32 ± 8 vs 19 ± 8 mm Hg, p <0.005 following nitroglycerin administration) were accomplanled by parallel alterations in HQ (48 ± 8 vs 54 ± 10 msec, p <0.005 following ventriculography and 57 ± 10 vs 53 ± msec, p <0.005 following nitroglycerin administration), but there were no significant changes in atrioventricular (AV) nodal conduction (AH). Significantly greater changes in HQ were seen in patients with triple-vessel coronary artery disease than in the remainder of the population, although there was clinical and/or ECG evidence of ischemia in only one patient. We conclude that factors other than progression of intrinsic conduction system disease may affect infranodal conduction. HQ should be interpreted cautiously in situations with rapidly changing hemodynamics, especially in patients with severe coronary artery disease.

Original languageEnglish (US)
Pages (from-to)464-470
Number of pages7
JournalAmerican Heart Journal
Volume106
Issue number3
DOIs
StatePublished - 1983
Externally publishedYes

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Sublingual Administration
Nitroglycerin
Coronary Artery Disease
Cardiac Electrophysiologic Techniques
Blood Pressure
Cardiac Catheterization
Chest Pain
Contrast Media
Electrocardiography
Ischemia
Hemodynamics
Injections
Population

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Acute changes in infranodal conduction time following left ventriculography and sublingual nitroglycerin administration in man. / Peters, Robert W.; Fisher, Michael L.; Resnick, Steven; Plotnick, Gary D.; Carliner, Nathan H.; Scheinman, Melvin M.

In: American Heart Journal, Vol. 106, No. 3, 1983, p. 464-470.

Research output: Contribution to journalArticle

Peters, Robert W. ; Fisher, Michael L. ; Resnick, Steven ; Plotnick, Gary D. ; Carliner, Nathan H. ; Scheinman, Melvin M. / Acute changes in infranodal conduction time following left ventriculography and sublingual nitroglycerin administration in man. In: American Heart Journal. 1983 ; Vol. 106, No. 3. pp. 464-470.
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