Acute changes in circulating hormones in older patients with impaired ventricular function undergoing on-pump coronary artery bypass grafting

M. Maggio, G. P. Ceda, G. De Cicco, E. Cattadori, S. Visioli, F. Ablondi, C. Beghi, T. Gherli, S. Basaria, G. Ceresini, G. Valenti, L. Ferrucci

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: Coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) causes an acute stress response characterized by changes in the levels of several hormones, which might play a role in the high complication rate experienced by older patients after CABG. Thus, the aim of the study was to investigate changes in the circulating levels of anabolic and catabolic hormones in old people undergoing CABG with CPB. Design: Intervention case study. Methods: 19 patients (12 males, 7 females) aged 70.1±6.1 yr (age range 62-80) with coronary artery disease and an ejection fraction 2), total testosterone (Te), SHBG, IGF-I were measured the day before, on the day of the procedure and 1, 2, 3, 4, and 30 days after CABG. Results: After surgery, serum IGF-I levels decreased (p2 significantly increased in both men and women. Alterations in Te levels differed between the two sexes with a significant decline in men and a significant increment in women. Conclusion: CABG with CPB resulted in a dramatic drop in Te levels in old men and a significant decline in IGF-I in both sexes. Serum Cort levels also significantly increased in both sexes. These hormonal changes may, at least partially, explain why the elderly need prolonged rehabilitation after CABG.

Original languageEnglish (US)
Pages (from-to)711-719
Number of pages9
JournalJournal of Endocrinological Investigation
Volume28
Issue number8
StatePublished - 2005
Externally publishedYes

Keywords

  • CABG
  • Cardiopulmonary bypass
  • Elderly
  • Hormones
  • IGF-I
  • Testoster-one

ASJC Scopus subject areas

  • Endocrinology

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