Acute bilineal leukemia: A rare disease with poor outcome

E. G. Weir, M. Ali Ansari-Lari, Denise Batista, C. A. Griffin, S. Fuller, B Douglas Smith, Michael J Borowitz

Research output: Contribution to journalArticle

Abstract

Most cases of acute leukemia can be assigned to the myeloid, B or T lineage. In a few cases, definitive assignment cannot be achieved because blasts express antigens of more than one lineage. A subset of these, referred to as acute bilineal leukemias (aBLLs), is characterized by the presence of more than one population of blasts, each comprising a single lineage. We identified 19 cases of aBLL, including 10 mixed T and myeloid (T-My) and nine mixed B and myeloid (B-My); no mixed B and T cases were identified. Cytogenetic data were available for 16 patients. Three of seven patients with B-My had a t(9;22)(q34q11.2), two had 11q23 translocations and one had del(9). Two of nine patients with T-My had 2p13 translocations; five had other unrelated abnormalities. Of 16 patients with outcome data, only six achieved complete remission and only two remain free of disease 2.5 and 4.5 years after chemotherapy or stem cell transplantation. aBLL is a rare disease that combines B or T and myeloid blasts. Cytogenetic abnormalities of t(9;22) and 11q23 are common in, and may be restricted to, B-My cases, while T-My cases have frequent but generally non-recurring abnormalities. Both types of aBLL are associated with poor outcome.

Original languageEnglish (US)
Pages (from-to)2264-2270
Number of pages7
JournalLeukemia
Volume21
Issue number11
DOIs
StatePublished - Nov 2007

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Rare Diseases
Leukemia
Stem Cell Transplantation
Cytogenetics
Chromosome Aberrations
Antigens
Drug Therapy
Population

ASJC Scopus subject areas

  • Hematology
  • Cancer Research

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Acute bilineal leukemia : A rare disease with poor outcome. / Weir, E. G.; Ali Ansari-Lari, M.; Batista, Denise; Griffin, C. A.; Fuller, S.; Smith, B Douglas; Borowitz, Michael J.

In: Leukemia, Vol. 21, No. 11, 11.2007, p. 2264-2270.

Research output: Contribution to journalArticle

Weir, EG, Ali Ansari-Lari, M, Batista, D, Griffin, CA, Fuller, S, Smith, BD & Borowitz, MJ 2007, 'Acute bilineal leukemia: A rare disease with poor outcome', Leukemia, vol. 21, no. 11, pp. 2264-2270. https://doi.org/10.1038/sj.leu.2404848
Weir EG, Ali Ansari-Lari M, Batista D, Griffin CA, Fuller S, Smith BD et al. Acute bilineal leukemia: A rare disease with poor outcome. Leukemia. 2007 Nov;21(11):2264-2270. https://doi.org/10.1038/sj.leu.2404848
Weir, E. G. ; Ali Ansari-Lari, M. ; Batista, Denise ; Griffin, C. A. ; Fuller, S. ; Smith, B Douglas ; Borowitz, Michael J. / Acute bilineal leukemia : A rare disease with poor outcome. In: Leukemia. 2007 ; Vol. 21, No. 11. pp. 2264-2270.
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