Acute and chronic hypoxic pulmonary vasoconstriction: A central role for endothelin-1?

Larissa A. Shimoda, James S.K. Sham, Qiang Liu, J. T. Sylvester

Research output: Contribution to journalArticlepeer-review

39 Scopus citations


In the pulmonary circulation, a decrease in oxygen tension results in the development of hypoxic pulmonary vasoconstriction (HPV), although the exact mechanism by which HPV occurs remains unclear. Evidence gathered from many laboratories suggests that while pulmonary arterial smooth muscle cells (PASMCs) can sense and respond to changes in oxygen tension, full expression of HPV requires modulating influences from the endothelium. In this review, we propose a model of HPV, based on recent studies from our laboratory, in which endothelin-1 (ET-1), a vasoactive peptide released from the endothelium, plays a central role and discuss how this model may be involved in the long-term adaptation to hypoxia.

Original languageEnglish (US)
Pages (from-to)93-106
Number of pages14
JournalRespiratory Physiology and Neurobiology
Issue number1
StatePublished - Aug 22 2002


  • Endothelium, pulmonary, endothelin-1
  • Hypoxia, pulmonary vasoconstriction, long-term adaptation
  • Modulators, endothelin
  • Pulmonary circulation, hypoxic vasoconstriction
  • Smooth muscle, pulmonary vessels

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Pulmonary and Respiratory Medicine


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