TY - JOUR
T1 - Acute and chronic hypoxic pulmonary vasoconstriction
T2 - A central role for endothelin-1?
AU - Shimoda, Larissa A.
AU - Sham, James S.K.
AU - Liu, Qiang
AU - Sylvester, J. T.
N1 - Funding Information:
This work was supported by grants from the NIH National Heart, Lung and Blood Institute HL51912 (to J.T.S) and HL52652 (to J.S.K.S.) and by a Scientist Development Grant from the American Heart Association awarded to L.A.S. (AHA9930255N).
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2002/8/22
Y1 - 2002/8/22
N2 - In the pulmonary circulation, a decrease in oxygen tension results in the development of hypoxic pulmonary vasoconstriction (HPV), although the exact mechanism by which HPV occurs remains unclear. Evidence gathered from many laboratories suggests that while pulmonary arterial smooth muscle cells (PASMCs) can sense and respond to changes in oxygen tension, full expression of HPV requires modulating influences from the endothelium. In this review, we propose a model of HPV, based on recent studies from our laboratory, in which endothelin-1 (ET-1), a vasoactive peptide released from the endothelium, plays a central role and discuss how this model may be involved in the long-term adaptation to hypoxia.
AB - In the pulmonary circulation, a decrease in oxygen tension results in the development of hypoxic pulmonary vasoconstriction (HPV), although the exact mechanism by which HPV occurs remains unclear. Evidence gathered from many laboratories suggests that while pulmonary arterial smooth muscle cells (PASMCs) can sense and respond to changes in oxygen tension, full expression of HPV requires modulating influences from the endothelium. In this review, we propose a model of HPV, based on recent studies from our laboratory, in which endothelin-1 (ET-1), a vasoactive peptide released from the endothelium, plays a central role and discuss how this model may be involved in the long-term adaptation to hypoxia.
KW - Endothelium, pulmonary, endothelin-1
KW - Hypoxia, pulmonary vasoconstriction, long-term adaptation
KW - Modulators, endothelin
KW - Pulmonary circulation, hypoxic vasoconstriction
KW - Smooth muscle, pulmonary vessels
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U2 - 10.1016/S1569-9048(02)00052-6
DO - 10.1016/S1569-9048(02)00052-6
M3 - Article
C2 - 12126698
AN - SCOPUS:0037158630
SN - 1569-9048
VL - 132
SP - 93
EP - 106
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 1
ER -