Acute administration of liposomal coenzyme Q10 increases myocardial tissue levels and improves tolerance to ischemia reperfusion injury

Koki Niibori, Hitoshi Yokoyama, Juan A. Crestanello, Glenn J.R. Whitman

Research output: Contribution to journalArticlepeer-review

Abstract

The antioxidant and bioenergetic effects of CoQ10 (CoQ) suggest it might be ideal therapy for acute myocardial ischemia. Its utility is limited by the requirement for enteral administration. This study related the administration of a new liposomal suspension of CoQ given intravenously to (1) serum and myocardial [CoQ] and (2) recovery of function, myocardial efficiency, and oxidant injury after cardiac ischemia and reperfusion (I/R). Rats (n = 8/group) were given liposomal CoQ 10 mg/kg iv or placebo (Control), 15 min (C-15), 30 min (C-30), and 60 min (C-60) before (1) measurement of serum and myocardial CoQ or (2) Langendorff perfusion of hearts subjected to 15 min equilibration, 25 min ischemia (37°C), and 40 min reperfusion (RP). Developed pressure (DP) was measured via an intraventricular balloon and coronary flow was measured by a digital flow meter. Myocardial efficiency was defined as DP/MVO2 where MVO2 = μl O2 consumed/min/gram LV. At end RP hearts were assayed for CK, an oxidant sensitive enzyme. Maximum preischemic CoQ levels in serum and myocardium occurred 15 and 30 min after administration, respectively. At end reperfusion, C-30 hearts improved the most, recovering 75 ± 4% of their preischemic DP while control recovered only 52 ± 6% (P < 0.03) as well as maintaining better myocardial efficiency (0.69 ± 0.02 vs Control, 0.43 ± 0.05) (P < 0.001). C-15, C-30, and C-60 groups all lost less CK activity after RP vs Control (P < 0.04). Conclusion: (1) Serum and myocardial levels of CoQ can be raised acutely by iv liposomal CoQ. (2) Myocardial CoQ levels correlate best with I/R protection. (3) Acute iv CoQ improves function and efficiency and decreases oxidant injury after UR. Intravenous CoQ may be effective clinically for acute cardiac ischemic syndromes.

Original languageEnglish (US)
Pages (from-to)141-145
Number of pages5
JournalJournal of Surgical Research
Volume79
Issue number2
DOIs
StatePublished - Oct 1998
Externally publishedYes

Keywords

  • Coenzyme Q10
  • Ischemia
  • Liposome
  • Reperfusion injury
  • Tissue level

ASJC Scopus subject areas

  • Surgery

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