TY - JOUR
T1 - Acute abdomen with colonic necrosis induced by Kayexalate-sorbitol
AU - Dardik, Alan
AU - Moesinger, Robert C.
AU - Efron, Gershon
AU - Barbul, Adrian
AU - Harrison, Miles G.
PY - 2000/5
Y1 - 2000/5
N2 - Colonic necrosis is an unusual complication after treatment of hyperkalemia with sodium polystyrene sulfonate (SPS, Kayexalate) in sorbitol. To increase awareness of this complication, we report a case of necrosis of the transverse colon in a patient given oral and rectal SPS-sorbitol for hyperkalemia. Colonic necrosis was manifested as an acute abdomen within 24 hours of initial administration. Prompt surgical resection of the necrotic transverse colon permitted rapid recovery of bowel function. Although SPS crystals are seen microscopically in the necrotic bowel, experimental evidence implicates the sorbitol component of the SPS-sorbitol in the pathogenesis of colonic necrosis. A high index of suspicion for the unusual complication of colonic necrosis after oral or rectal administration of SPS- sorbitol may allow prompt recognition and surgical cure.
AB - Colonic necrosis is an unusual complication after treatment of hyperkalemia with sodium polystyrene sulfonate (SPS, Kayexalate) in sorbitol. To increase awareness of this complication, we report a case of necrosis of the transverse colon in a patient given oral and rectal SPS-sorbitol for hyperkalemia. Colonic necrosis was manifested as an acute abdomen within 24 hours of initial administration. Prompt surgical resection of the necrotic transverse colon permitted rapid recovery of bowel function. Although SPS crystals are seen microscopically in the necrotic bowel, experimental evidence implicates the sorbitol component of the SPS-sorbitol in the pathogenesis of colonic necrosis. A high index of suspicion for the unusual complication of colonic necrosis after oral or rectal administration of SPS- sorbitol may allow prompt recognition and surgical cure.
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U2 - 10.1097/00007611-200093050-00016
DO - 10.1097/00007611-200093050-00016
M3 - Article
C2 - 10832954
AN - SCOPUS:0034083229
SN - 0038-4348
VL - 93
SP - 511
EP - 513
JO - Southern medical journal
JF - Southern medical journal
IS - 5
ER -