Activity of the dihydropyridine calcium channels following cerebral ischemia

M. Hogan, A. Gjedde, A. Hakim

Research output: Contribution to journalArticle

Abstract

With an in-vivo autoradiographic method the binding of 3H-nimodipine (CAS 66085-59-4) and cerebral blood flow (14C-iodoantipyrine method) were measured in rat brain after occlusion of the middle cerebral and common carotid arteries. The dependence of the binding to neuronal cellular membranes on the duration of ischemia can be interpreted as indicator of the tissue's functional state or its responsiveness to therapy with calcium entry blockers. In the two analyzed structures, dorsolateral caudate and overlying sensorimotor cortex, the appearance of infarction is preceded by an activation of the nimodipine binding sites followed by persistent decline of the binding intensity. Binding to nimodipine may therefore be a useful marker of ischemic but salvageable brain tissue.

Original languageEnglish (US)
Pages (from-to)332-333
Number of pages2
JournalArzneimittel-Forschung/Drug Research
Volume41
Issue number3 A
StatePublished - 1991
Externally publishedYes

Fingerprint

Nimodipine
Calcium Channels
Brain Ischemia
Brain
Cerebrovascular Circulation
Tissue
Common Carotid Artery
Infarction
Rats
Blood
Ischemia
Chemical activation
Binding Sites
Calcium
Membranes
1,4-dihydropyridine
Therapeutics

ASJC Scopus subject areas

  • Chemistry(all)
  • Organic Chemistry
  • Drug Discovery
  • Pharmacology

Cite this

Activity of the dihydropyridine calcium channels following cerebral ischemia. / Hogan, M.; Gjedde, A.; Hakim, A.

In: Arzneimittel-Forschung/Drug Research, Vol. 41, No. 3 A, 1991, p. 332-333.

Research output: Contribution to journalArticle

Hogan, M. ; Gjedde, A. ; Hakim, A. / Activity of the dihydropyridine calcium channels following cerebral ischemia. In: Arzneimittel-Forschung/Drug Research. 1991 ; Vol. 41, No. 3 A. pp. 332-333.
@article{87f001c695c541db817cfa8892d6635a,
title = "Activity of the dihydropyridine calcium channels following cerebral ischemia",
abstract = "With an in-vivo autoradiographic method the binding of 3H-nimodipine (CAS 66085-59-4) and cerebral blood flow (14C-iodoantipyrine method) were measured in rat brain after occlusion of the middle cerebral and common carotid arteries. The dependence of the binding to neuronal cellular membranes on the duration of ischemia can be interpreted as indicator of the tissue's functional state or its responsiveness to therapy with calcium entry blockers. In the two analyzed structures, dorsolateral caudate and overlying sensorimotor cortex, the appearance of infarction is preceded by an activation of the nimodipine binding sites followed by persistent decline of the binding intensity. Binding to nimodipine may therefore be a useful marker of ischemic but salvageable brain tissue.",
author = "M. Hogan and A. Gjedde and A. Hakim",
year = "1991",
language = "English (US)",
volume = "41",
pages = "332--333",
journal = "Drug Research",
issn = "2194-9379",
publisher = "Thieme",
number = "3 A",

}

TY - JOUR

T1 - Activity of the dihydropyridine calcium channels following cerebral ischemia

AU - Hogan, M.

AU - Gjedde, A.

AU - Hakim, A.

PY - 1991

Y1 - 1991

N2 - With an in-vivo autoradiographic method the binding of 3H-nimodipine (CAS 66085-59-4) and cerebral blood flow (14C-iodoantipyrine method) were measured in rat brain after occlusion of the middle cerebral and common carotid arteries. The dependence of the binding to neuronal cellular membranes on the duration of ischemia can be interpreted as indicator of the tissue's functional state or its responsiveness to therapy with calcium entry blockers. In the two analyzed structures, dorsolateral caudate and overlying sensorimotor cortex, the appearance of infarction is preceded by an activation of the nimodipine binding sites followed by persistent decline of the binding intensity. Binding to nimodipine may therefore be a useful marker of ischemic but salvageable brain tissue.

AB - With an in-vivo autoradiographic method the binding of 3H-nimodipine (CAS 66085-59-4) and cerebral blood flow (14C-iodoantipyrine method) were measured in rat brain after occlusion of the middle cerebral and common carotid arteries. The dependence of the binding to neuronal cellular membranes on the duration of ischemia can be interpreted as indicator of the tissue's functional state or its responsiveness to therapy with calcium entry blockers. In the two analyzed structures, dorsolateral caudate and overlying sensorimotor cortex, the appearance of infarction is preceded by an activation of the nimodipine binding sites followed by persistent decline of the binding intensity. Binding to nimodipine may therefore be a useful marker of ischemic but salvageable brain tissue.

UR - http://www.scopus.com/inward/record.url?scp=0025972039&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025972039&partnerID=8YFLogxK

M3 - Article

C2 - 1650224

AN - SCOPUS:0025972039

VL - 41

SP - 332

EP - 333

JO - Drug Research

JF - Drug Research

SN - 2194-9379

IS - 3 A

ER -