TY - JOUR
T1 - Activity of new quinolones against intracellular Mycobacterium avium in human monocytes
AU - Venkataprasad, Nandagopal
AU - Jacobs, Michael R.
AU - Johnson, John L.
AU - Klopman, Gilles
AU - Ellner, Jerrold J.
PY - 1997/12
Y1 - 1997/12
N2 - The ability to inhibit the in-vitro growth of mycobacteria within human monocytes is a useful screening assay for novel chemotherapeutic agents. In this study the MICs of a panel of new quinolones were determined by the broth microdilution method for two strains of Mycobacterium avium. Sixteen such compounds with MIC90S ranging from 2 to > 32 mg/L were subsequently selected for the 7 day monocyte assay using ciprofloxacin for comparison. The degree of inhibition of intracellular growth correlated with the MICs. PD 139586, PD 143289, PD 135144, PD 119421 and PD 131575 were the most active new agents with activities superior to those of ciprofloxacin and sparfloxacin.
AB - The ability to inhibit the in-vitro growth of mycobacteria within human monocytes is a useful screening assay for novel chemotherapeutic agents. In this study the MICs of a panel of new quinolones were determined by the broth microdilution method for two strains of Mycobacterium avium. Sixteen such compounds with MIC90S ranging from 2 to > 32 mg/L were subsequently selected for the 7 day monocyte assay using ciprofloxacin for comparison. The degree of inhibition of intracellular growth correlated with the MICs. PD 139586, PD 143289, PD 135144, PD 119421 and PD 131575 were the most active new agents with activities superior to those of ciprofloxacin and sparfloxacin.
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U2 - 10.1093/jac/40.6.841
DO - 10.1093/jac/40.6.841
M3 - Article
C2 - 9462436
AN - SCOPUS:0031435245
VL - 40
SP - 841
EP - 845
JO - Journal of Antimicrobial Chemotherapy
JF - Journal of Antimicrobial Chemotherapy
SN - 0305-7453
IS - 6
ER -