Activity of 2-acetylpyridine and 2 acetylquinoline thiosemicarbazones tested in vitro in combination with other antituberculous drugs

F. M. Collins, D. L. Klayman, N. E. Morrison

Research output: Contribution to journalArticle

Abstract

Determinations of minimal inhibitory concentrations (MIC) were carried out using three new 2 acetylpyridine and two new 2-acetylquinoline thiosemicarbazones tested against Mycobacterium tuberculosis, M. kansasii, M. simiae, M. avium, and M. intracellulare. Two of the compounds (Compounds L 31) 30) exhibited MIC ≤ 5 μg per ml for all of the test organisms, except for M. simiae, which was resistant to antituberculous drugs. The other thiosemicarbazones (Compounds 3L, 2N, 3G, and 2H) were relatively inactive against the nontuberculous mycobacteria. Rifampin, amikacin, and clofazimine were active when tested singly or in combination with Compounds L and 31. Addition of compound 31 to a mixture of rifampin, amikacin, and clofazimine resulted in combination MIC of less than 0.6 μg/mg against all of the nontuberculous mycobacteria, suggesting that combinations of this type may be suitable for the treatment of infections caused by these highly drug resistant organisms.

Original languageEnglish (US)
Pages (from-to)58-60
Number of pages3
JournalAmerican Review of Respiratory Disease
Volume125
Issue number1
StatePublished - 1982
Externally publishedYes

Fingerprint

Clofazimine
Thiosemicarbazones
Nontuberculous Mycobacteria
Amikacin
Rifampin
Galectin 3
Mycobacterium tuberculosis
Pharmaceutical Preparations
Infection
2-acetylpyridine
In Vitro Techniques

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Activity of 2-acetylpyridine and 2 acetylquinoline thiosemicarbazones tested in vitro in combination with other antituberculous drugs. / Collins, F. M.; Klayman, D. L.; Morrison, N. E.

In: American Review of Respiratory Disease, Vol. 125, No. 1, 1982, p. 58-60.

Research output: Contribution to journalArticle

@article{ce3bf7c0a63347b4946510fb5d3c4378,
title = "Activity of 2-acetylpyridine and 2 acetylquinoline thiosemicarbazones tested in vitro in combination with other antituberculous drugs",
abstract = "Determinations of minimal inhibitory concentrations (MIC) were carried out using three new 2 acetylpyridine and two new 2-acetylquinoline thiosemicarbazones tested against Mycobacterium tuberculosis, M. kansasii, M. simiae, M. avium, and M. intracellulare. Two of the compounds (Compounds L 31) 30) exhibited MIC ≤ 5 μg per ml for all of the test organisms, except for M. simiae, which was resistant to antituberculous drugs. The other thiosemicarbazones (Compounds 3L, 2N, 3G, and 2H) were relatively inactive against the nontuberculous mycobacteria. Rifampin, amikacin, and clofazimine were active when tested singly or in combination with Compounds L and 31. Addition of compound 31 to a mixture of rifampin, amikacin, and clofazimine resulted in combination MIC of less than 0.6 μg/mg against all of the nontuberculous mycobacteria, suggesting that combinations of this type may be suitable for the treatment of infections caused by these highly drug resistant organisms.",
author = "Collins, {F. M.} and Klayman, {D. L.} and Morrison, {N. E.}",
year = "1982",
language = "English (US)",
volume = "125",
pages = "58--60",
journal = "American Journal of Respiratory and Critical Care Medicine",
issn = "1073-449X",
publisher = "American Thoracic Society",
number = "1",

}

TY - JOUR

T1 - Activity of 2-acetylpyridine and 2 acetylquinoline thiosemicarbazones tested in vitro in combination with other antituberculous drugs

AU - Collins, F. M.

AU - Klayman, D. L.

AU - Morrison, N. E.

PY - 1982

Y1 - 1982

N2 - Determinations of minimal inhibitory concentrations (MIC) were carried out using three new 2 acetylpyridine and two new 2-acetylquinoline thiosemicarbazones tested against Mycobacterium tuberculosis, M. kansasii, M. simiae, M. avium, and M. intracellulare. Two of the compounds (Compounds L 31) 30) exhibited MIC ≤ 5 μg per ml for all of the test organisms, except for M. simiae, which was resistant to antituberculous drugs. The other thiosemicarbazones (Compounds 3L, 2N, 3G, and 2H) were relatively inactive against the nontuberculous mycobacteria. Rifampin, amikacin, and clofazimine were active when tested singly or in combination with Compounds L and 31. Addition of compound 31 to a mixture of rifampin, amikacin, and clofazimine resulted in combination MIC of less than 0.6 μg/mg against all of the nontuberculous mycobacteria, suggesting that combinations of this type may be suitable for the treatment of infections caused by these highly drug resistant organisms.

AB - Determinations of minimal inhibitory concentrations (MIC) were carried out using three new 2 acetylpyridine and two new 2-acetylquinoline thiosemicarbazones tested against Mycobacterium tuberculosis, M. kansasii, M. simiae, M. avium, and M. intracellulare. Two of the compounds (Compounds L 31) 30) exhibited MIC ≤ 5 μg per ml for all of the test organisms, except for M. simiae, which was resistant to antituberculous drugs. The other thiosemicarbazones (Compounds 3L, 2N, 3G, and 2H) were relatively inactive against the nontuberculous mycobacteria. Rifampin, amikacin, and clofazimine were active when tested singly or in combination with Compounds L and 31. Addition of compound 31 to a mixture of rifampin, amikacin, and clofazimine resulted in combination MIC of less than 0.6 μg/mg against all of the nontuberculous mycobacteria, suggesting that combinations of this type may be suitable for the treatment of infections caused by these highly drug resistant organisms.

UR - http://www.scopus.com/inward/record.url?scp=0020043327&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0020043327&partnerID=8YFLogxK

M3 - Article

VL - 125

SP - 58

EP - 60

JO - American Journal of Respiratory and Critical Care Medicine

JF - American Journal of Respiratory and Critical Care Medicine

SN - 1073-449X

IS - 1

ER -