Abstract
Two new cardenolides, (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-rhamnosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20 (22)-enolide (1), (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-glucopyranosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20(22)-enolide (2), and a known cardenolide, (-)-17β-neriifolin (3), were isolated from the roots of Cerbera manghas as antiproliferative and anti-estrogenic principles when evaluated against a human colon cancer cell line (Col2) and the Ishikawa cell line, respectively. Two known lignans, (-)-olivil (4) and (-)-cycloolivil (5), were also isolated but were inactive in the assay systems used. (C) 2000 Elsevier Science Ltd.
Original language | English (US) |
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Pages (from-to) | 2431-2434 |
Number of pages | 4 |
Journal | Bioorganic and Medicinal Chemistry Letters |
Volume | 10 |
Issue number | 21 |
DOIs | |
State | Published - Nov 6 2000 |
Externally published | Yes |
ASJC Scopus subject areas
- Biochemistry
- Molecular Medicine
- Molecular Biology
- Pharmaceutical Science
- Drug Discovery
- Clinical Biochemistry
- Organic Chemistry