Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities

Leng Chee Chang; Joell J. Gills; Krishna P.L. Bhat; Lumonadio Luyengi; Norman R. Farnsworth; John M. Pezzuto; A. Douglas Kinghorn

doi:10.1016/S0960-894X(00)00477-7

Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities

Leng Chee Chang, Joell J. Gills, Krishna P.L. Bhat, Lumonadio Luyengi, Norman R. Farnsworth, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journal › Article › peer-review

Abstract

Two new cardenolides, (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-rhamnosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20 (22)-enolide (1), (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-glucopyranosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20(22)-enolide (2), and a known cardenolide, (-)-17β-neriifolin (3), were isolated from the roots of Cerbera manghas as antiproliferative and anti-estrogenic principles when evaluated against a human colon cancer cell line (Col2) and the Ishikawa cell line, respectively. Two known lignans, (-)-olivil (4) and (-)-cycloolivil (5), were also isolated but were inactive in the assay systems used. (C) 2000 Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	2431-2434
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	21
DOIs	https://doi.org/10.1016/S0960-894X(00)00477-7
State	Published - Nov 6 2000
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Molecular Medicine
Molecular Biology
Pharmaceutical Science
Drug Discovery
Clinical Biochemistry
Organic Chemistry

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Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities. / Chang, Leng Chee; Gills, Joell J.; Bhat, Krishna P.L.; Luyengi, Lumonadio; Farnsworth, Norman R.; Pezzuto, John M.; Kinghorn, A. Douglas.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 10, No. 21, 06.11.2000, p. 2431-2434.

Research output: Contribution to journal › Article › peer-review

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abstract = "Two new cardenolides, (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-rhamnosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20 (22)-enolide (1), (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-glucopyranosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20(22)-enolide (2), and a known cardenolide, (-)-17β-neriifolin (3), were isolated from the roots of Cerbera manghas as antiproliferative and anti-estrogenic principles when evaluated against a human colon cancer cell line (Col2) and the Ishikawa cell line, respectively. Two known lignans, (-)-olivil (4) and (-)-cycloolivil (5), were also isolated but were inactive in the assay systems used. (C) 2000 Elsevier Science Ltd.",

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AU - Chang, Leng Chee

AU - Gills, Joell J.

AU - Bhat, Krishna P.L.

AU - Luyengi, Lumonadio

AU - Farnsworth, Norman R.

AU - Pezzuto, John M.

AU - Kinghorn, A. Douglas

PY - 2000/11/6

Y1 - 2000/11/6

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