Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities

Leng Chee Chang, Joell J. Gills, Krishna P.L. Bhat, Lumonadio Luyengi, Norman R. Farnsworth, John M. Pezzuto, A. Douglas Kinghorn

Research output: Contribution to journalArticlepeer-review

Abstract

Two new cardenolides, (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-rhamnosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20 (22)-enolide (1), (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-glucopyranosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20(22)-enolide (2), and a known cardenolide, (-)-17β-neriifolin (3), were isolated from the roots of Cerbera manghas as antiproliferative and anti-estrogenic principles when evaluated against a human colon cancer cell line (Col2) and the Ishikawa cell line, respectively. Two known lignans, (-)-olivil (4) and (-)-cycloolivil (5), were also isolated but were inactive in the assay systems used. (C) 2000 Elsevier Science Ltd.

Original languageEnglish (US)
Pages (from-to)2431-2434
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume10
Issue number21
DOIs
StatePublished - Nov 6 2000
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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