TY - JOUR
T1 - Activity-guided isolation of constituents of Cerbera manghas with antiproliferative and antiestrogenic activities
AU - Chang, Leng Chee
AU - Gills, Joell J.
AU - Bhat, Krishna P.L.
AU - Luyengi, Lumonadio
AU - Farnsworth, Norman R.
AU - Pezzuto, John M.
AU - Kinghorn, A. Douglas
N1 - Funding Information:
We are grateful to Dr. D. D. Soejarto and Mr. R. B. Dvorak, College of Pharmacy, University of Illinois at Chicago, for taxonomic assistance and for the mass spectral data, respectively. The Nuclear Magnetic Resonance Laboratory of the Research Resources Center, University of Illinois at Chicago, is thanked for assistance and for the provision of spectroscopic equipment used in this study. This investigation was supported by program project P01 CA48112, funded by the National Cancer Institute, NIH, Bethesda, MD.
PY - 2000/11/6
Y1 - 2000/11/6
N2 - Two new cardenolides, (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-rhamnosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20 (22)-enolide (1), (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-glucopyranosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20(22)-enolide (2), and a known cardenolide, (-)-17β-neriifolin (3), were isolated from the roots of Cerbera manghas as antiproliferative and anti-estrogenic principles when evaluated against a human colon cancer cell line (Col2) and the Ishikawa cell line, respectively. Two known lignans, (-)-olivil (4) and (-)-cycloolivil (5), were also isolated but were inactive in the assay systems used. (C) 2000 Elsevier Science Ltd.
AB - Two new cardenolides, (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-rhamnosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20 (22)-enolide (1), (-)-14-hydroxy-3β-(3-O-methyl-6-deoxy-α-L-glucopyranosyl)-11α, 12α-epoxy-(5β, 14β, 17βH)-card-20(22)-enolide (2), and a known cardenolide, (-)-17β-neriifolin (3), were isolated from the roots of Cerbera manghas as antiproliferative and anti-estrogenic principles when evaluated against a human colon cancer cell line (Col2) and the Ishikawa cell line, respectively. Two known lignans, (-)-olivil (4) and (-)-cycloolivil (5), were also isolated but were inactive in the assay systems used. (C) 2000 Elsevier Science Ltd.
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U2 - 10.1016/S0960-894X(00)00477-7
DO - 10.1016/S0960-894X(00)00477-7
M3 - Article
C2 - 11078194
AN - SCOPUS:0034613560
VL - 10
SP - 2431
EP - 2434
JO - Bioorganic and Medicinal Chemistry Letters
JF - Bioorganic and Medicinal Chemistry Letters
SN - 0960-894X
IS - 21
ER -