Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death

Gordon W. Glazner; Andre Boland; Albert E. Dresse; Douglas E. Brenneman; Illana Gozes; Mark P. Mattson

doi:10.1046/j.1471-4159.1999.0732341.x

Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death

Gordon W. Glazner, Andre Boland, Albert E. Dresse, Douglas E. Brenneman, Illana Gozes, Mark P. Mattson

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

Activity-dependent neurotrophic factor (ADNF) and a 14-amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid β-peptide, N-methyl-D-aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine-amino acid fragment (ADNF9) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO₄ and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species.

Original language	English (US)
Pages (from-to)	2341-2347
Number of pages	7
Journal	Journal of Neurochemistry
Volume	73
Issue number	6
DOIs	https://doi.org/10.1046/j.1471-4159.1999.0732341.x
State	Published - 1999
Externally published	Yes

Keywords

Activity-dependent neurotrophic factor
Apoptosis
Neurons
Reactive oxygen species
Trophic factor withdrawal

ASJC Scopus subject areas

Biochemistry
Cellular and Molecular Neuroscience

Access to Document

10.1046/j.1471-4159.1999.0732341.x

Cite this

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title = "Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death",

abstract = "Activity-dependent neurotrophic factor (ADNF) and a 14-amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid β-peptide, N-methyl-D-aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine-amino acid fragment (ADNF9) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO4 and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species.",

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AU - Glazner, Gordon W.

AU - Boland, Andre

AU - Dresse, Albert E.

AU - Brenneman, Douglas E.

AU - Gozes, Illana

AU - Mattson, Mark P.

PY - 1999

Y1 - 1999

N2 - Activity-dependent neurotrophic factor (ADNF) and a 14-amino acid fragment of this peptide (sequence VLGGGSALLRSIPA) protect neurons from death associated with an array of toxic conditions, including amyloid β-peptide, N-methyl-D-aspartate, tetrodotoxin, and the neurotoxic HIV envelope coat protein gp120. We report that an even smaller, nine-amino acid fragment (ADNF9) with the sequence SALLRSIPA potently protects cultured embryonic day 18 rat hippocampal neurons from oxidative injury and neuronal apoptosis induced by FeSO4 and trophic factor withdrawal. Among the characteristics of this protection are maintenance of mitochondrial function and a reduction in accumulation of intracellular reactive oxygen species.

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KW - Activity-dependent neurotrophic factor

KW - Apoptosis

KW - Neurons

KW - Reactive oxygen species

KW - Trophic factor withdrawal

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Activity-dependent neurotrophic factor peptide (ADNF9) protects neurons against oxidative stress-induced death

Abstract

Keywords

ASJC Scopus subject areas

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