Activity-dependent neuronal signalling and autism spectrum disorder

Daniel H. Ebert, Michael E. Greenberg

Research output: Contribution to journalReview articlepeer-review

Abstract

Neuronal activity induces the post-translational modification of synaptic molecules, promotes localized protein synthesis within dendrites and activates gene transcription, thereby regulating synaptic function and allowing neuronal circuits to respond dynamically to experience. Evidence indicates that many of the genes that are mutated in autism spectrum disorder are crucial components of the activity-dependent signalling networks that regulate synapse development and plasticity. Dysregulation of activity-dependent signalling pathways in neurons may, therefore, have a key role in the aetiology of autism spectrum disorder.

Original languageEnglish (US)
Pages (from-to)327-337
Number of pages11
JournalNature
Volume493
Issue number7432
DOIs
StatePublished - Jan 17 2013
Externally publishedYes

ASJC Scopus subject areas

  • General

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