Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis

Dengke K. Ma, Woon Ryoung Kim, Guo Li Ming, Hongjun Song

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The adult mammalian brain continuously generates new neurons in the olfactory bulb and hippocampus throughout life. Adult neurogenesis, a highly dynamic process, has been shown to be exquisitely modulated by neuronal circuit activity at different stages, from proliferation of adult neural progenitors, to differentiation, maturation, integration, and survival of newborn neurons in the adult brain. Strategic activity-dependent addition of new neurons into the existing neuronal circuitry represents a prominent form of structural plasticity and may contribute to specific brain functions, such as learning, memory, and mood modulation. Here we review extrinsic mechanisms through which adult neurogenesis is regulated by environmental cues, physiological learning-related stimuli, and neuronal activities.

Original languageEnglish (US)
Title of host publicationAnnals of the New York Academy of Sciences
Pages664-673
Number of pages10
Volume1170
DOIs
StatePublished - Jul 2009

Publication series

NameAnnals of the New York Academy of Sciences
Volume1170
ISSN (Print)00778923
ISSN (Electronic)17496632

Fingerprint

Olfactory Bulb
Neurogenesis
Neurons
Brain
Learning
Cues
Plasticity
Hippocampus
Modulation
Data storage equipment
Networks (circuits)

Keywords

  • Adult stem cells
  • Neural activity
  • Neurogenesis
  • Neurotransmitter
  • Plasticity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ma, D. K., Kim, W. R., Ming, G. L., & Song, H. (2009). Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis. In Annals of the New York Academy of Sciences (Vol. 1170, pp. 664-673). (Annals of the New York Academy of Sciences; Vol. 1170). https://doi.org/10.1111/j.1749-6632.2009.04373.x

Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis. / Ma, Dengke K.; Kim, Woon Ryoung; Ming, Guo Li; Song, Hongjun.

Annals of the New York Academy of Sciences. Vol. 1170 2009. p. 664-673 (Annals of the New York Academy of Sciences; Vol. 1170).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ma, DK, Kim, WR, Ming, GL & Song, H 2009, Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis. in Annals of the New York Academy of Sciences. vol. 1170, Annals of the New York Academy of Sciences, vol. 1170, pp. 664-673. https://doi.org/10.1111/j.1749-6632.2009.04373.x
Ma DK, Kim WR, Ming GL, Song H. Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis. In Annals of the New York Academy of Sciences. Vol. 1170. 2009. p. 664-673. (Annals of the New York Academy of Sciences). https://doi.org/10.1111/j.1749-6632.2009.04373.x
Ma, Dengke K. ; Kim, Woon Ryoung ; Ming, Guo Li ; Song, Hongjun. / Activity-dependent extrinsic regulation of adult olfactory bulb and hippocampal neurogenesis. Annals of the New York Academy of Sciences. Vol. 1170 2009. pp. 664-673 (Annals of the New York Academy of Sciences).
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