Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice

L. Struillou, Y. Cohen, N. Lounis, G. Bertrand, J. Grosset, J. L. Vilde -, J. J. Pocidalo, C. Perronne

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Abstract

The activity of roxithromycin against three clinical isolates of Mycobacterium avium was compared with that of clarithromycin both in a model of infection of human monocyte-derived macrophages and in a model of established infection of C57BL/6 mice. In the cell culture model, roxithromycin and clarithromycin were bactericidal for strains MO-1 and N- 92159 and bacteriostatic for strain N-93043. For the three strains, the differences between the intracellular activities of roxithromycin and clarithromycin were not significant after 7 days of treatment. Mice were infected with the MO-1 strain. Drugs were given by gavage at a dosage of 200 mg/kg of body weight 6 days per week for 16 weeks starting 5 weeks after infection. At the end of treatment, clarithromycin was more effective than roxithromycin in lungs; roxithromycin was as effective as clarithromycin in spleens. Thus, the activity of roxithromycin was comparable to that of clarithromycin both in vitro and in vivo.

Original languageEnglish (US)
Pages (from-to)878-881
Number of pages4
JournalAntimicrobial agents and chemotherapy
Volume39
Issue number4
DOIs
StatePublished - Jan 1 1995

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ASJC Scopus subject areas

  • Pharmacology
  • Pharmacology (medical)
  • Infectious Diseases

Cite this

Struillou, L., Cohen, Y., Lounis, N., Bertrand, G., Grosset, J., Vilde -, J. L., Pocidalo, J. J., & Perronne, C. (1995). Activities of roxithromycin against Mycobacterium avium infections in human macrophages and C57BL/6 mice. Antimicrobial agents and chemotherapy, 39(4), 878-881. https://doi.org/10.1128/AAC.39.4.878