Activities of clarithromycin, sulfisoxazole, and rifabutin against Mycobacterium avium complex multiplication within human macrophages

C. Perronne, A. Gikas, C. Truffot-Pernot, J. Grosset, J. J. Pocidalo, J. L. Vilde

Research output: Contribution to journalArticle

Abstract

The activities of clarithromycin, sulfisoxazole, and rifabutin against three virulent strains of Mycobacterium avium complex isolated from patients with acquired immunodeficiency syndrome were evaluated in a model of intracellular infection. Human monocyte-derived macrophages were infected at day 6 of culture with M. avium complex. Intracellular bacteria were counted 60 min after inoculation. Extra- and intracellular bacteria were counted at days 4 and 7 after inoculation. The concentrations used were 4 μg of clarithromycin per ml (KICs for the three strains, 4, 4, and 4 μg/ml), 50 μg of sulfisoxazole per ml (MICs, 50, 25, and 25 μg/ml), and 0.5 μg of rifabutin per ml (MICs, 2, 0.5, and 0.5 μg/ml). compared with controls, clarithromycin and rifabutin slowed the intracellular replication of the three strains (at day 7 after inoculation, P was

Original languageEnglish (US)
Pages (from-to)1508-1511
Number of pages4
JournalAntimicrobial Agents and Chemotherapy
Volume34
Issue number8
StatePublished - 1990
Externally publishedYes

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Sulfisoxazole
Rifabutin
Mycobacterium avium Complex
Clarithromycin
Macrophages
Bacteria
Acquired Immunodeficiency Syndrome
Infection

ASJC Scopus subject areas

  • Pharmacology (medical)

Cite this

Perronne, C., Gikas, A., Truffot-Pernot, C., Grosset, J., Pocidalo, J. J., & Vilde, J. L. (1990). Activities of clarithromycin, sulfisoxazole, and rifabutin against Mycobacterium avium complex multiplication within human macrophages. Antimicrobial Agents and Chemotherapy, 34(8), 1508-1511.

Activities of clarithromycin, sulfisoxazole, and rifabutin against Mycobacterium avium complex multiplication within human macrophages. / Perronne, C.; Gikas, A.; Truffot-Pernot, C.; Grosset, J.; Pocidalo, J. J.; Vilde, J. L.

In: Antimicrobial Agents and Chemotherapy, Vol. 34, No. 8, 1990, p. 1508-1511.

Research output: Contribution to journalArticle

Perronne, C, Gikas, A, Truffot-Pernot, C, Grosset, J, Pocidalo, JJ & Vilde, JL 1990, 'Activities of clarithromycin, sulfisoxazole, and rifabutin against Mycobacterium avium complex multiplication within human macrophages', Antimicrobial Agents and Chemotherapy, vol. 34, no. 8, pp. 1508-1511.
Perronne, C. ; Gikas, A. ; Truffot-Pernot, C. ; Grosset, J. ; Pocidalo, J. J. ; Vilde, J. L. / Activities of clarithromycin, sulfisoxazole, and rifabutin against Mycobacterium avium complex multiplication within human macrophages. In: Antimicrobial Agents and Chemotherapy. 1990 ; Vol. 34, No. 8. pp. 1508-1511.
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