Active telephone surveillance to evaluate adverse events among civilian smallpox vaccine recipients

Arnulfo A. Muralles, Paula Ray, Steven Black, Henry Shinefield, Christine G. Casey, Scott Campbell, Robert T. Chen, Colin Marchant, Jerome Klein, Elizabeth Barnett, Phillip LaRussa, Anne Gershon, Neal Halsey, Robert Davis, Cornelia L. Dekker, Margaret Rennels, Kathryn Edwards

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


Objective: Better characterize and monitor adverse events following Dryvax ® vaccinia vaccination in civilian health care workers and other first responders. Design: Telephone interviews to ascertain adverse events experienced. Results: Eight hundred twenty-five vaccinees, including 44 in the comparison group, were interviewed. At 10 days, 71.4% reported blisters, 35.1% reported bumps at the vaccination site, 48.5% swelling, 47.3% scab, tiredness/lethargy/fatigue (43.6%), headache (34.2%), lymph node swelling/tenderness (28.5%), muscle pain (23.1%), chills (14.4%), joint pain 11.8%, and fever >100°F (12.5%). The 12.5% reported missing work because of vaccine adverse events. Most adverse events were anticipated and of short duration.

Original languageEnglish (US)
Pages (from-to)476-484
Number of pages9
Issue number4
StatePublished - Jan 23 2006


  • Safety
  • Smallpox
  • Vaccinia

ASJC Scopus subject areas

  • Molecular Medicine
  • Immunology and Microbiology(all)
  • veterinary(all)
  • Public Health, Environmental and Occupational Health
  • Infectious Diseases


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