Active specific immunotherapy of guinea pigs with visceral tumor implants

Eliyahu Yarkoni, James T. Hunter, Saraswati Sukumar, Herbert J. Rapp

Research output: Contribution to journalArticlepeer-review


Guinea pigs, each with established, 7-day-old, syngeneic visceral micrometastases of line 10 tumor implanted intravenously, were immunized by intradermal inoculations into several sites of a mixture of irradiated line 10 cells and an emulsion containing heat-killed BCG or Mycobacterium phlei bacilli. This treatment led to survival of 72 of 80 treated animals (90%). Therapeutic effectiveness depended on the dose of mycobacteria and on that of irradiated tumor cells. Animals treated by intradermal injection of mycobacteria attached to oil droplets alone or with irradiated tumor cells alone, all died with multiple foci of pulmonary tumor.

Original languageEnglish (US)
Pages (from-to)273-275
Number of pages3
JournalCancer Immunology Immunotherapy
Issue number3
StatePublished - Apr 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Oncology
  • Cancer Research


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