Active enhancement of dog kidney allografts using ALG and donor platelets

W. Rowinski, T. Ryffa, S. Stepkowski, B. Woźniewicz, M. Ruka, B. Wasowska, M. Hay, W. Olszewski

Research output: Contribution to journalArticlepeer-review

Abstract

The results of the studies indicate that platelets can be used as donor specific antigen in protocols of 'biological suppression'. Administration of donor specific platelets 10 days after transplantation to unmatched mongrel dogs treated for a brief period with ALG resulted in a marked prolongation of kidney allograft survival. Acute rejection of a second kidney from an indifferent donor suggests that a state of specific unresponsiveness was achieved by recipient pretreatment with ALG and donor antigen challenge.

Original languageEnglish (US)
Pages (from-to)1013-1019
Number of pages7
JournalArchivum Immunologiae et Therapiae Experimentalis
Volume26
Issue number1-6
StatePublished - 1979
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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