@inproceedings{0af35aaca3b94c41a9070ebad4eef272,
title = "Activator protein-1 mediates docosahexaenoic acid-induced apoptosis of human gastric cancer cells",
abstract = "Docosahexaenoic acid (DHA) shows anti-inflammatory and/or anticancer effects in some cells. Activator protein-1 (AP-1) regulates cellular proliferation and apoptosis. Although recent studies demonstrate the association between gastric cancer risk and DHA, the exact molecular mechanism has not been clarified. We investigated whether AP-1 mediates DHA-induced apoptosis of gastric cancer cells. We found that DHA induced cell death and DNA fragmentation in parallel with the activation of extracellular signal-regulated kinases (ERK) and c-Jun N-terminal kinases (JNK) as well as AP-1. DHA increased the protein levels of p53, cytochrome c, and Bax in gastric cancer cells. DHA-induced DNA fragmentation and protein levels of p53, cytochrome c, and Bax were inhibited in the cells transfected with c-jun dominant-negative mutant (TAM67). Because JNK and ERK are upstream signaling for AP-1 activation, we suggest that DHA-induced activation of AP-1 may mediate apoptosis of gastric cancer cells by inducing the expression of apoptotic genes in gastric cancer cells.",
keywords = "AP-1, Apoptosis, DHA, Gastric cancer cells",
author = "Lee, {Sun En} and Lim, {Joo Weon} and Hyeyoung Kim",
year = "2009",
month = aug,
doi = "10.1111/j.1749-6632.2009.04716.x",
language = "English (US)",
isbn = "9781573317375",
series = "Annals of the New York Academy of Sciences",
publisher = "Blackwell Publishing Inc.",
pages = "163--169",
booktitle = "Natural Compounds and Their Role in Apoptotic Cell Signaling Pathways",
}