Activation of the liver X receptor by agonist TO901317 improves hepatic insulin resistance via suppressing reactive oxygen species and JNK pathway

Medicine & Life Sciences

• TO-901317 100%
• Liver X Receptors 83%
• MAP Kinase Signaling System 67%
• Insulin Resistance 50%
• Reactive Oxygen Species 49%
• Liver 31%
• Palmitates 30%
• Hep G2 Cells 19%
• Glucose 15%
• Gene Expression 11%
• Fasting 9%
• Insulin 8%
• Gluconeogenesis 7%
• Drug Development 5%
• In Vitro Techniques 5%
• Blood Glucose 5%
• Rodentia 5%
• Psychological Inhibition 4%
• Genes 2%
• Therapeutics 2%

Agriculture & Biology

• insulin resistance 75%
• agonists 56%
• reactive oxygen species 50%
• receptors 41%
• palmitates 23%
• mice 14%
• glucose 12%
• blood glucose 10%
• fasting 10%
• gene expression 9%
• metabolism 8%
• insulin 8%
• inactivation 8%
• drug development 6%
• cells 6%
• hypoglycemic agents 6%
• gluconeogenesis 6%
• diabetes 5%
• mechanism of action 4%
• rodents 4%
• therapeutics 3%
• transcription factors 3%
• genes 1%

Chemical Compounds

• Insulin Derivative 62%
• Agonist 58%
• Reactive Oxygen Metabolite 57%
• Glucose 45%
• Resistance 38%
• Pharmacological Metabolism 28%
• Liver X Receptor Agonist 23%
• Antioxidant Agent 18%
• Antidiabetic Agent 14%
• Metabolic 9%