The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed. Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the κB sites. The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cu-acting negative regulatory element.
|Original language||English (US)|
|Number of pages||5|
|Journal||Journal of Virology|
|State||Published - Jun 1992|
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