Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1

David M. Markovitz, Mark C. Hannibal, Michael J. Smith, Ronald Cossman, Gary J. Nabel

Research output: Contribution to journalArticle

Abstract

The function of a putative NFAT-1 site in the human immunodeficiency virus type 1 enhancer has been analyzed. Activation by the T-cell antigen receptor is minimal in Jurkat cells and is mediated by the κB sites. The putative NFAT-1 region is not required for the response to anti-CD3 or to mitogens in T-cell, B-cell, or monocyte/macrophage leukemia lines, nor is it a cu-acting negative regulatory element.

Original languageEnglish (US)
Pages (from-to)3961-3965
Number of pages5
JournalJournal of Virology
Volume66
Issue number6
StatePublished - Jun 1992
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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  • Cite this

    Markovitz, D. M., Hannibal, M. C., Smith, M. J., Cossman, R., & Nabel, G. J. (1992). Activation of the human immunodeficiency virus type 1 enhancer is not dependent on NFAT-1. Journal of Virology, 66(6), 3961-3965.