Activation of the EGFR/p38/JNK pathway by mitochondrial-derived hydrogen peroxide contributes to oxygen-induced contraction of ductus arteriosus

Medicine & Life Sciences

• Ductus Arteriosus 100%
• Hydrogen Peroxide 74%
• ErbB Receptors 70%
• Phosphotransferases 57%
• Oxygen 52%
• Calcium 19%
• RTKI cpd 16%
• MAP Kinase Kinase 4 16%
• Smooth Muscle Myocytes 15%
• Patent Ductus Arteriosus 13%
• JNK Mitogen-Activated Protein Kinases 12%
• p38 Mitogen-Activated Protein Kinases 11%
• Vasoconstriction 11%
• Phosphoric Monoester Hydrolases 11%
• Epidermal Growth Factor 11%
• Oxidation-Reduction 10%
• Protein-Tyrosine Kinases 10%
• tyrphostin A23 10%
• protein kinase N 8%
• Anisomycin 8%
• Phosphorylation 7%
• Vanadates 7%
• SB 203580 7%
• rho-Associated Kinases 7%
• Genistein 6%
• Ion Channels 5%
• Constriction 5%
• Catalase 5%
• Protein Kinases 5%
• Tyrosine 5%
• Transcriptional Activation 5%
• Small Interfering RNA 4%
• Hypoxia 4%
• Rabbits 4%
• Therapeutics 1%

Chemical Compounds

• Hydrogen Peroxide 56%
• Calcium(0) 23%
• Dioxygen 14%
• Tyrosine 11%
• (-)-Anisomycin 10%
• Tyrosine Kinase Inhibitor 8%
• Genistein 8%
• Phosphotransferase Inhibitor 7%
• Sensitization 6%
• White 5%
• Protein 5%
• Ion 2%