Activation of PPARγ specifies a dendritic cell subtype capable of enhanced induction of iNKT cell expansion

Istvan Szatmari, Peter Gogolak, Jin Seol Im, Balazs Dezso, Eva Rajnavolgyi, Laszlo Nagy

Research output: Contribution to journalArticlepeer-review

Abstract

Little is known of the transcriptional events controlling the differentiation and function of dendritic cells (DC). We found that the ligand-activated transcription factor Peroxisome Proliferator Activated Receptor γ (PPARγ) is immediately upregulated after the induction of monocyte-derived DC differentiation. Activation of PPARγ changed the expression pattern of cell surface receptors and enhanced the internalizing activity of DC. Unexpectedly, we found that CD1 glycoproteins, a class of molecules responsible for the presentation of self and foreign modified lipids, were coordinately regulated by PPARγ activation. CD1a levels were reduced, while CD1d expression was induced. Enhanced expression of CD1d was coupled to the selective induction of invariant natural-killer T cell (iNKT cell) proliferation in the presence of α-GalCer. These results suggest that PPARγ orchestrates a transcriptional response leading to the development of a DC subtype with increased internalizing capacity, efficient lipid presentation, and the augmented potential to activate iNKT cells.

Original languageEnglish (US)
Pages (from-to)95-106
Number of pages12
JournalImmunity
Volume21
Issue number1
DOIs
StatePublished - Jul 2004
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Infectious Diseases

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