Activation of nuclear receptor coactivator PGC-1α by arginine methylation

Catherine Teyssier, Han Ma, Roger Emter, Anastasia Kralli, Michael R. Stallcup

Research output: Contribution to journalArticlepeer-review

Abstract

Peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a tissue-specific and inducible transcriptional coactivator for several nuclear receptors, plays a key role in energy metabolism. We report here that PGC-1α coactivator activity is potentiated by arginine methylation by protein arginine methyltransferase 1 (PRMT1), another nuclear receptor coactivator. Mutation of three substrate arginines in the C-terminal region of PGC-1α abolished the cooperative coactivator function of PGC-1α and PRMT1, and compromised the ability of PGC-1α to induce endogenous target genes. Finally, endogenous PRMT1 contributes to PGC-1α coactivator activity, and to the induction of genes important for mitochondrial biogenesis.

Original languageEnglish (US)
Pages (from-to)1466-1473
Number of pages8
JournalGenes and Development
Volume19
Issue number12
DOIs
StatePublished - Jun 15 2005
Externally publishedYes

Keywords

  • Arginine methylation
  • Coactivator
  • Mitochondrial biogenesis
  • Nuclear receptor
  • Transcription

ASJC Scopus subject areas

  • Genetics
  • Developmental Biology

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