Activation of c‐Ki‐ras not detectable in adenomas or adenocarcinomas arising in rat pancreas

Barbara K. Schaeffer, Joanne Zurlo, Daniel S. Longnecker

Research output: Contribution to journalArticlepeer-review

Abstract

The objective of this study was to determine whether activation of c‐Ki‐ras occurs in carcinogen‐induced rat pancreatic tumors. DNAs from 27 samples, which included adenomas, carcinomas in situ, and adenocarcinomas arising in azaserine‐treated rats and corn oil‐gavaged rats along with a nafenopin‐induced rat pancreatic adenocarcinoma were examined for mutation of c‐Ki‐ras at codons 12, 13, and 61 by using the polymerase chain reaction. Our results indicate that activation of c‐Ki‐ras is not a common event during pancreatic carcinogenesis in the rat.

Original languageEnglish (US)
Pages (from-to)165-170
Number of pages6
JournalMolecular Carcinogenesis
Volume3
Issue number3
DOIs
StatePublished - 1990

Keywords

  • Key words
  • Polymerase chain reaction
  • mutation
  • oncogene

ASJC Scopus subject areas

  • Molecular Biology
  • Cancer Research

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