TY - JOUR
T1 - Activation of c‐Ki‐ras not detectable in adenomas or adenocarcinomas arising in rat pancreas
AU - Schaeffer, Barbara K.
AU - Zurlo, Joanne
AU - Longnecker, Daniel S.
PY - 1990
Y1 - 1990
N2 - The objective of this study was to determine whether activation of c‐Ki‐ras occurs in carcinogen‐induced rat pancreatic tumors. DNAs from 27 samples, which included adenomas, carcinomas in situ, and adenocarcinomas arising in azaserine‐treated rats and corn oil‐gavaged rats along with a nafenopin‐induced rat pancreatic adenocarcinoma were examined for mutation of c‐Ki‐ras at codons 12, 13, and 61 by using the polymerase chain reaction. Our results indicate that activation of c‐Ki‐ras is not a common event during pancreatic carcinogenesis in the rat.
AB - The objective of this study was to determine whether activation of c‐Ki‐ras occurs in carcinogen‐induced rat pancreatic tumors. DNAs from 27 samples, which included adenomas, carcinomas in situ, and adenocarcinomas arising in azaserine‐treated rats and corn oil‐gavaged rats along with a nafenopin‐induced rat pancreatic adenocarcinoma were examined for mutation of c‐Ki‐ras at codons 12, 13, and 61 by using the polymerase chain reaction. Our results indicate that activation of c‐Ki‐ras is not a common event during pancreatic carcinogenesis in the rat.
KW - Key words
KW - Polymerase chain reaction
KW - mutation
KW - oncogene
UR - http://www.scopus.com/inward/record.url?scp=0025315142&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0025315142&partnerID=8YFLogxK
U2 - 10.1002/mc.2940030310
DO - 10.1002/mc.2940030310
M3 - Article
C2 - 2196902
AN - SCOPUS:0025315142
SN - 0899-1987
VL - 3
SP - 165
EP - 170
JO - Molecular Carcinogenesis
JF - Molecular Carcinogenesis
IS - 3
ER -