Activation of β-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis

H. Mayanja-Kizza, A. Wajja, M. Wu, P. Peters, G. Nalugwa, F. Mubiru, H. Aung, G. Vanham, C. Hirsch, C. Whalen, J. Ellner, Z. Toossi

Research output: Contribution to journalArticlepeer-review

Abstract

Tuberculosis (TB) in human immunodeficiency virus type 1 (HIV-1)-infected persons is associated with progression of HIV-1 disease. The expression of macrophage inflammatory protein (MIP)-1α and CCR5 was assessed in HIV-1-infected patients with pulmonary TB (HIV-1/PTB) and without PTB (HIV-1/C), PTB patients not infected with HIV-1 (PTB), and control subjects. Mycobacterium tuberculosis (MTB)-induced MIP-1α production was lower in peripheral blood mononuclear cells (PBMC) of HIV-1/PTB patients than in those of PTB patients (P <.05) and was lower in PBMC of HIV-1/C patients than in those of control subjects (P <.005). However, MIP-1α production was higher in PBMC of HIV/PTB patients than in those of HIV-1/C patients (P <.01). The pattern of MTB-induced RANTES production was similar to that of MIP-1α. However, MTB induced greater expression of mRNA for CCR5 in PBMC of HIV-1/PTB patients than in those of HIV-1/C patients (P <.04). Furthermore, the MTB-induced HIV p24 antigen level in PBMC of HIV-1/PTB patients with a CD4 cell count

Original languageEnglish (US)
Pages (from-to)1801-1804
Number of pages4
JournalJournal of Infectious Diseases
Volume183
Issue number12
DOIs
StatePublished - Jun 15 2001
Externally publishedYes

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

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