Activation of β-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis

H. Mayanja-Kizza, A. Wajja, M. Wu, P. Peters, G. Nalugwa, F. Mubiru, H. Aung, G. Vanham, C. Hirsch, C. Whalen, J. Ellner, Z. Toossi

Research output: Contribution to journalArticle

Abstract

Tuberculosis (TB) in human immunodeficiency virus type 1 (HIV-1)-infected persons is associated with progression of HIV-1 disease. The expression of macrophage inflammatory protein (MIP)-1α and CCR5 was assessed in HIV-1-infected patients with pulmonary TB (HIV-1/PTB) and without PTB (HIV-1/C), PTB patients not infected with HIV-1 (PTB), and control subjects. Mycobacterium tuberculosis (MTB)-induced MIP-1α production was lower in peripheral blood mononuclear cells (PBMC) of HIV-1/PTB patients than in those of PTB patients (P <.05) and was lower in PBMC of HIV-1/C patients than in those of control subjects (P <.005). However, MIP-1α production was higher in PBMC of HIV/PTB patients than in those of HIV-1/C patients (P <.01). The pattern of MTB-induced RANTES production was similar to that of MIP-1α. However, MTB induced greater expression of mRNA for CCR5 in PBMC of HIV-1/PTB patients than in those of HIV-1/C patients (P <.04). Furthermore, the MTB-induced HIV p24 antigen level in PBMC of HIV-1/PTB patients with a CD4 cell count

Original languageEnglish (US)
Pages (from-to)1801-1804
Number of pages4
JournalJournal of Infectious Diseases
Volume183
Issue number12
DOIs
StatePublished - Jun 15 2001
Externally publishedYes

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Chemokines
HIV-1
Tuberculosis
Macrophage Inflammatory Proteins
Blood Cells
Mycobacterium tuberculosis
HIV Core Protein p24
Chemokine CCL5
Virus Diseases
CD4 Lymphocyte Count
Pulmonary Tuberculosis
HIV
Messenger RNA

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Mayanja-Kizza, H., Wajja, A., Wu, M., Peters, P., Nalugwa, G., Mubiru, F., ... Toossi, Z. (2001). Activation of β-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis. Journal of Infectious Diseases, 183(12), 1801-1804. https://doi.org/10.1086/320724

Activation of β-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis. / Mayanja-Kizza, H.; Wajja, A.; Wu, M.; Peters, P.; Nalugwa, G.; Mubiru, F.; Aung, H.; Vanham, G.; Hirsch, C.; Whalen, C.; Ellner, J.; Toossi, Z.

In: Journal of Infectious Diseases, Vol. 183, No. 12, 15.06.2001, p. 1801-1804.

Research output: Contribution to journalArticle

Mayanja-Kizza, H, Wajja, A, Wu, M, Peters, P, Nalugwa, G, Mubiru, F, Aung, H, Vanham, G, Hirsch, C, Whalen, C, Ellner, J & Toossi, Z 2001, 'Activation of β-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis', Journal of Infectious Diseases, vol. 183, no. 12, pp. 1801-1804. https://doi.org/10.1086/320724
Mayanja-Kizza, H. ; Wajja, A. ; Wu, M. ; Peters, P. ; Nalugwa, G. ; Mubiru, F. ; Aung, H. ; Vanham, G. ; Hirsch, C. ; Whalen, C. ; Ellner, J. ; Toossi, Z. / Activation of β-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis. In: Journal of Infectious Diseases. 2001 ; Vol. 183, No. 12. pp. 1801-1804.
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