Activation of β-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis

H. Mayanja-Kizza; A. Wajja; M. Wu; P. Peters; G. Nalugwa; F. Mubiru; H. Aung; G. Vanham; C. Hirsch; C. Whalen; J. Ellner; Z. Toossi

doi:10.1086/320724

Activation of β-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis

H. Mayanja-Kizza, A. Wajja, M. Wu, P. Peters, G. Nalugwa, F. Mubiru, H. Aung, G. Vanham, C. Hirsch, C. Whalen, J. Ellner, Z. Toossi

Research output: Contribution to journal › Article › peer-review

31 Scopus citations

Abstract

Tuberculosis (TB) in human immunodeficiency virus type 1 (HIV-1)-infected persons is associated with progression of HIV-1 disease. The expression of macrophage inflammatory protein (MIP)-1α and CCR5 was assessed in HIV-1-infected patients with pulmonary TB (HIV-1/PTB) and without PTB (HIV-1/C), PTB patients not infected with HIV-1 (PTB), and control subjects. Mycobacterium tuberculosis (MTB)-induced MIP-1α production was lower in peripheral blood mononuclear cells (PBMC) of HIV-1/PTB patients than in those of PTB patients (P <.05) and was lower in PBMC of HIV-1/C patients than in those of control subjects (P <.005). However, MIP-1α production was higher in PBMC of HIV/PTB patients than in those of HIV-1/C patients (P <.01). The pattern of MTB-induced RANTES production was similar to that of MIP-1α. However, MTB induced greater expression of mRNA for CCR5 in PBMC of HIV-1/PTB patients than in those of HIV-1/C patients (P <.04). Furthermore, the MTB-induced HIV p24 antigen level in PBMC of HIV-1/PTB patients with a CD4 cell count

Original language	English (US)
Pages (from-to)	1801-1804
Number of pages	4
Journal	Journal of Infectious Diseases
Volume	183
Issue number	12
DOIs	https://doi.org/10.1086/320724
State	Published - Jun 15 2001
Externally published	Yes

ASJC Scopus subject areas

Public Health, Environmental and Occupational Health
Immunology

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10.1086/320724

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title = "Activation of β-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis",

abstract = "Tuberculosis (TB) in human immunodeficiency virus type 1 (HIV-1)-infected persons is associated with progression of HIV-1 disease. The expression of macrophage inflammatory protein (MIP)-1α and CCR5 was assessed in HIV-1-infected patients with pulmonary TB (HIV-1/PTB) and without PTB (HIV-1/C), PTB patients not infected with HIV-1 (PTB), and control subjects. Mycobacterium tuberculosis (MTB)-induced MIP-1α production was lower in peripheral blood mononuclear cells (PBMC) of HIV-1/PTB patients than in those of PTB patients (P <.05) and was lower in PBMC of HIV-1/C patients than in those of control subjects (P <.005). However, MIP-1α production was higher in PBMC of HIV/PTB patients than in those of HIV-1/C patients (P <.01). The pattern of MTB-induced RANTES production was similar to that of MIP-1α. However, MTB induced greater expression of mRNA for CCR5 in PBMC of HIV-1/PTB patients than in those of HIV-1/C patients (P <.04). Furthermore, the MTB-induced HIV p24 antigen level in PBMC of HIV-1/PTB patients with a CD4 cell count ",

author = "H. Mayanja-Kizza and A. Wajja and M. Wu and P. Peters and G. Nalugwa and F. Mubiru and H. Aung and G. Vanham and C. Hirsch and C. Whalen and J. Ellner and Z. Toossi",

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T1 - Activation of β-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis

AU - Mayanja-Kizza, H.

AU - Wajja, A.

AU - Wu, M.

AU - Peters, P.

AU - Nalugwa, G.

AU - Mubiru, F.

AU - Aung, H.

AU - Vanham, G.

AU - Hirsch, C.

AU - Whalen, C.

AU - Ellner, J.

AU - Toossi, Z.

PY - 2001/6/15

Y1 - 2001/6/15

N2 - Tuberculosis (TB) in human immunodeficiency virus type 1 (HIV-1)-infected persons is associated with progression of HIV-1 disease. The expression of macrophage inflammatory protein (MIP)-1α and CCR5 was assessed in HIV-1-infected patients with pulmonary TB (HIV-1/PTB) and without PTB (HIV-1/C), PTB patients not infected with HIV-1 (PTB), and control subjects. Mycobacterium tuberculosis (MTB)-induced MIP-1α production was lower in peripheral blood mononuclear cells (PBMC) of HIV-1/PTB patients than in those of PTB patients (P <.05) and was lower in PBMC of HIV-1/C patients than in those of control subjects (P <.005). However, MIP-1α production was higher in PBMC of HIV/PTB patients than in those of HIV-1/C patients (P <.01). The pattern of MTB-induced RANTES production was similar to that of MIP-1α. However, MTB induced greater expression of mRNA for CCR5 in PBMC of HIV-1/PTB patients than in those of HIV-1/C patients (P <.04). Furthermore, the MTB-induced HIV p24 antigen level in PBMC of HIV-1/PTB patients with a CD4 cell count

AB - Tuberculosis (TB) in human immunodeficiency virus type 1 (HIV-1)-infected persons is associated with progression of HIV-1 disease. The expression of macrophage inflammatory protein (MIP)-1α and CCR5 was assessed in HIV-1-infected patients with pulmonary TB (HIV-1/PTB) and without PTB (HIV-1/C), PTB patients not infected with HIV-1 (PTB), and control subjects. Mycobacterium tuberculosis (MTB)-induced MIP-1α production was lower in peripheral blood mononuclear cells (PBMC) of HIV-1/PTB patients than in those of PTB patients (P <.05) and was lower in PBMC of HIV-1/C patients than in those of control subjects (P <.005). However, MIP-1α production was higher in PBMC of HIV/PTB patients than in those of HIV-1/C patients (P <.01). The pattern of MTB-induced RANTES production was similar to that of MIP-1α. However, MTB induced greater expression of mRNA for CCR5 in PBMC of HIV-1/PTB patients than in those of HIV-1/C patients (P <.04). Furthermore, the MTB-induced HIV p24 antigen level in PBMC of HIV-1/PTB patients with a CD4 cell count

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Activation of β-chemokines and CCR5 in persons infected with human immunodeficiency virus type 1 and tuberculosis

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