Activated TLR signaling in atherosclerosis among women with lower framingham risk score: The multi-ethnic study of atherosclerosis

Chiang Ching Huang, Kiang Liu, Richard M. Pope, Pan Du, Simon Lin, Nalini M. Rajamannan, Qi Quan Huang, Nadereh Jafari, Gregory L. Burke, Wendy S Post, Karol E. Watson, Craig Johnson, Martha L. Daviglus, Donald M. Lloyd-Jones

Research output: Contribution to journalArticle

Abstract

Background: Atherosclerosis is the leading cause of cardiovascular disease (CVD). Traditional risk factors can be used to identify individuals at high risk for developing CVD and are generally associated with the extent of atherosclerosis; however, substantial numbers of individuals at low or intermediate risk still develop atherosclerosis. Results: A case-control study was performed using microarray gene expression profiling of peripheral blood from 119 healthy women in the Multi-Ethnic Study of Atherosclerosis cohort aged 50 or above. All participants had low (100 and carotid intima-media thickness (IMT) >1.0 mm, whereas controls (N = 71) had CAC

Original languageEnglish (US)
Article numbere21067
JournalPLoS One
Volume6
Issue number6
DOIs
StatePublished - 2011

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atherosclerosis
Atherosclerosis
cardiovascular diseases
Cardiovascular Diseases
Microarrays
Gene expression
Carotid Intima-Media Thickness
Gene Expression Profiling
Blood
case-control studies
Case-Control Studies
Cohort Studies
risk factors
gene expression
blood

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Huang, C. C., Liu, K., Pope, R. M., Du, P., Lin, S., Rajamannan, N. M., ... Lloyd-Jones, D. M. (2011). Activated TLR signaling in atherosclerosis among women with lower framingham risk score: The multi-ethnic study of atherosclerosis. PLoS One, 6(6), [e21067]. https://doi.org/10.1371/journal.pone.0021067

Activated TLR signaling in atherosclerosis among women with lower framingham risk score : The multi-ethnic study of atherosclerosis. / Huang, Chiang Ching; Liu, Kiang; Pope, Richard M.; Du, Pan; Lin, Simon; Rajamannan, Nalini M.; Huang, Qi Quan; Jafari, Nadereh; Burke, Gregory L.; Post, Wendy S; Watson, Karol E.; Johnson, Craig; Daviglus, Martha L.; Lloyd-Jones, Donald M.

In: PLoS One, Vol. 6, No. 6, e21067, 2011.

Research output: Contribution to journalArticle

Huang, CC, Liu, K, Pope, RM, Du, P, Lin, S, Rajamannan, NM, Huang, QQ, Jafari, N, Burke, GL, Post, WS, Watson, KE, Johnson, C, Daviglus, ML & Lloyd-Jones, DM 2011, 'Activated TLR signaling in atherosclerosis among women with lower framingham risk score: The multi-ethnic study of atherosclerosis', PLoS One, vol. 6, no. 6, e21067. https://doi.org/10.1371/journal.pone.0021067
Huang, Chiang Ching ; Liu, Kiang ; Pope, Richard M. ; Du, Pan ; Lin, Simon ; Rajamannan, Nalini M. ; Huang, Qi Quan ; Jafari, Nadereh ; Burke, Gregory L. ; Post, Wendy S ; Watson, Karol E. ; Johnson, Craig ; Daviglus, Martha L. ; Lloyd-Jones, Donald M. / Activated TLR signaling in atherosclerosis among women with lower framingham risk score : The multi-ethnic study of atherosclerosis. In: PLoS One. 2011 ; Vol. 6, No. 6.
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