Activated platelets trigger an inflammatory response and enhance migration of aortic smooth muscle cells

Steffen Massberg, Felix Vogt, Timm Dickfeld, Korbinian Brand, Sharon Page, Meinrad Gawaz

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Exposure of the subendothelium to flowing blood following rupture of atherosclerotic lesions or during balloon angioplasty initiates platelet adhesion to the vascular wall. Because activated platelets release proinflammatory mediators (e.g., interleukin (IL)-1β) and secrete growth factors, platelet adhesion to the subendothelial matrix might contribute to the recruitment of inflammatory cells and promote migration and proliferation of vascular smooth muscle cells (SMCs). Methods and Results: Here, we demonstrate that incubation of cultured monolayers of aortic SMCs with α-thrombin- activated platelets significantly enhances the secretion of monocyte chemoattractant protein-1 (MCP-1) (P

Original languageEnglish (US)
Pages (from-to)187-194
Number of pages8
JournalThrombosis Research
Volume110
Issue number4
DOIs
StatePublished - Jun 1 2003
Externally publishedYes

Keywords

  • Atherosclerosis
  • Migration
  • Monocyte chemotaxis
  • Platelets
  • Restenosis
  • Smooth muscle

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Hematology

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