Activated platelets trigger an inflammatory response and enhance migration of aortic smooth muscle cells

Steffen Massberg; Felix Vogt; Timm Dickfeld; Korbinian Brand; Sharon Page; Meinrad Gawaz

doi:10.1016/S0049-3848(03)00342-6

Activated platelets trigger an inflammatory response and enhance migration of aortic smooth muscle cells

Steffen Massberg, Felix Vogt, Timm Dickfeld, Korbinian Brand, Sharon Page, Meinrad Gawaz

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: Exposure of the subendothelium to flowing blood following rupture of atherosclerotic lesions or during balloon angioplasty initiates platelet adhesion to the vascular wall. Because activated platelets release proinflammatory mediators (e.g., interleukin (IL)-1β) and secrete growth factors, platelet adhesion to the subendothelial matrix might contribute to the recruitment of inflammatory cells and promote migration and proliferation of vascular smooth muscle cells (SMCs). Methods and Results: Here, we demonstrate that incubation of cultured monolayers of aortic SMCs with α-thrombin- activated platelets significantly enhances the secretion of monocyte chemoattractant protein-1 (MCP-1) (P

Original language	English (US)
Pages (from-to)	187-194
Number of pages	8
Journal	Thrombosis Research
Volume	110
Issue number	4
DOIs	https://doi.org/10.1016/S0049-3848(03)00342-6
State	Published - Jun 1 2003
Externally published	Yes

Keywords

Atherosclerosis
Migration
Monocyte chemotaxis
Platelets
Restenosis
Smooth muscle

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Hematology

Access to Document

10.1016/S0049-3848(03)00342-6

Cite this

@article{e70812b799dd45988d85d75ef83d0180,

title = "Activated platelets trigger an inflammatory response and enhance migration of aortic smooth muscle cells",

abstract = "Objective: Exposure of the subendothelium to flowing blood following rupture of atherosclerotic lesions or during balloon angioplasty initiates platelet adhesion to the vascular wall. Because activated platelets release proinflammatory mediators (e.g., interleukin (IL)-1β) and secrete growth factors, platelet adhesion to the subendothelial matrix might contribute to the recruitment of inflammatory cells and promote migration and proliferation of vascular smooth muscle cells (SMCs). Methods and Results: Here, we demonstrate that incubation of cultured monolayers of aortic SMCs with α-thrombin- activated platelets significantly enhances the secretion of monocyte chemoattractant protein-1 (MCP-1) (P",

keywords = "Atherosclerosis, Migration, Monocyte chemotaxis, Platelets, Restenosis, Smooth muscle",

author = "Steffen Massberg and Felix Vogt and Timm Dickfeld and Korbinian Brand and Sharon Page and Meinrad Gawaz",

year = "2003",

month = jun,

day = "1",

doi = "10.1016/S0049-3848(03)00342-6",

language = "English (US)",

volume = "110",

pages = "187--194",

journal = "Thrombosis Research",

issn = "0049-3848",

publisher = "Elsevier Limited",

number = "4",

}

TY - JOUR

T1 - Activated platelets trigger an inflammatory response and enhance migration of aortic smooth muscle cells

AU - Massberg, Steffen

AU - Vogt, Felix

AU - Dickfeld, Timm

AU - Brand, Korbinian

AU - Page, Sharon

AU - Gawaz, Meinrad

PY - 2003/6/1

Y1 - 2003/6/1

N2 - Objective: Exposure of the subendothelium to flowing blood following rupture of atherosclerotic lesions or during balloon angioplasty initiates platelet adhesion to the vascular wall. Because activated platelets release proinflammatory mediators (e.g., interleukin (IL)-1β) and secrete growth factors, platelet adhesion to the subendothelial matrix might contribute to the recruitment of inflammatory cells and promote migration and proliferation of vascular smooth muscle cells (SMCs). Methods and Results: Here, we demonstrate that incubation of cultured monolayers of aortic SMCs with α-thrombin- activated platelets significantly enhances the secretion of monocyte chemoattractant protein-1 (MCP-1) (P

AB - Objective: Exposure of the subendothelium to flowing blood following rupture of atherosclerotic lesions or during balloon angioplasty initiates platelet adhesion to the vascular wall. Because activated platelets release proinflammatory mediators (e.g., interleukin (IL)-1β) and secrete growth factors, platelet adhesion to the subendothelial matrix might contribute to the recruitment of inflammatory cells and promote migration and proliferation of vascular smooth muscle cells (SMCs). Methods and Results: Here, we demonstrate that incubation of cultured monolayers of aortic SMCs with α-thrombin- activated platelets significantly enhances the secretion of monocyte chemoattractant protein-1 (MCP-1) (P

KW - Atherosclerosis

KW - Migration

KW - Monocyte chemotaxis

KW - Platelets

KW - Restenosis

KW - Smooth muscle

UR - http://www.scopus.com/inward/record.url?scp=0242317417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0242317417&partnerID=8YFLogxK

U2 - 10.1016/S0049-3848(03)00342-6

DO - 10.1016/S0049-3848(03)00342-6

M3 - Article

C2 - 14512080

AN - SCOPUS:0242317417

VL - 110

SP - 187

EP - 194

JO - Thrombosis Research

JF - Thrombosis Research

SN - 0049-3848

IS - 4

ER -

Activated platelets trigger an inflammatory response and enhance migration of aortic smooth muscle cells

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this