Activated marrow-infiltrating lymphocytes effectively target plasma cells and their clonogenic precursors

Kimberly Noonan, William Matsui, Paolo Serafini, Rebecca Carbley, Gladys Tan, Jahan Khalili, Mark Bonyhadi, Hyam Levitsky, Katie Whartenby, Ivan Borrello

Research output: Contribution to journalArticle

Abstract

A major limitation of adoptive immunotherapy is the availability of T cells specific for both terminally differentiated tumor cells and their clonogenic precursors. We show here that marrow-infiltrating lymphocytes (MILs) recognize myeloma cells after activation with anti-CD3/CD28 beads with higher frequency than activated peripheral blood lymphocytes from the same patients. Furthermore, activated MILs target both the terminally differentiated CD138+ plasma cells and the myeloma precursor as shown by profound inhibition in a tumor clonogenic assay. The presence of antigen in the marrow microenvironment seems to be important for the maintenance of tumor specificity. Taken together, these results highlight the intrinsic tumor specificity of MILs and describe a novel approach for the generation of tumor-specific T-cell populations suitable for adoptive immunotherapy of multiple myeloma.

Original languageEnglish (US)
Pages (from-to)2026-2034
Number of pages9
JournalCancer Research
Volume65
Issue number5
DOIs
StatePublished - Mar 1 2005

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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