Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine.

Saraswati Sukumar, A. Perantoni, C. Reed, J. M. Rice, M. L. Wenk

Research output: Contribution to journalArticle

Abstract

Administration of methyl(methoxymethyl)nitrosamine to newborn Fischer 344 rats results in the preferential induction of renal tumors arising from the mesenchymal component of the kidney. DNA from a significant proportion of these tumors was capable of transforming NIH/3T3 cells. This report describes the renal tumor model, the detection of two different ras transforming genes in the kidney tumors (the N-ras oncogene in 1 and K-ras oncogene in 10 kidney tumors) and the characterization of DNA sequences specifying the transformed phenotype.

Original languageEnglish (US)
Pages (from-to)2716-2720
Number of pages5
JournalMolecular and Cellular Biology
Volume6
Issue number7
StatePublished - Jul 1986
Externally publishedYes

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Nitrosamines
ras Genes
Inbred F344 Rats
Kidney
Neoplasms
NIH 3T3 Cells
Oncogenes
Phenotype
DNA

ASJC Scopus subject areas

  • Cell Biology
  • Genetics
  • Molecular Biology

Cite this

Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine. / Sukumar, Saraswati; Perantoni, A.; Reed, C.; Rice, J. M.; Wenk, M. L.

In: Molecular and Cellular Biology, Vol. 6, No. 7, 07.1986, p. 2716-2720.

Research output: Contribution to journalArticle

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