Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine.

S. Sukumar; A. Perantoni; C. Reed; J. M. Rice; M. L. Wenk

doi:10.1128/MCB.6.7.2716

Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine.

S. Sukumar, A. Perantoni, C. Reed, J. M. Rice, M. L. Wenk

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Abstract

Administration of methyl(methoxymethyl)nitrosamine to newborn Fischer 344 rats results in the preferential induction of renal tumors arising from the mesenchymal component of the kidney. DNA from a significant proportion of these tumors was capable of transforming NIH/3T3 cells. This report describes the renal tumor model, the detection of two different ras transforming genes in the kidney tumors (the N-ras oncogene in 1 and K-ras oncogene in 10 kidney tumors) and the characterization of DNA sequences specifying the transformed phenotype.

Original language	English (US)
Pages (from-to)	2716-2720
Number of pages	5
Journal	Molecular and cellular biology
Volume	6
Issue number	7
DOIs	https://doi.org/10.1128/MCB.6.7.2716
State	Published - Jul 1986
Externally published	Yes

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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AU - Rice, J. M.

AU - Wenk, M. L.

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AB - Administration of methyl(methoxymethyl)nitrosamine to newborn Fischer 344 rats results in the preferential induction of renal tumors arising from the mesenchymal component of the kidney. DNA from a significant proportion of these tumors was capable of transforming NIH/3T3 cells. This report describes the renal tumor model, the detection of two different ras transforming genes in the kidney tumors (the N-ras oncogene in 1 and K-ras oncogene in 10 kidney tumors) and the characterization of DNA sequences specifying the transformed phenotype.

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Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine.

Abstract

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