Activated K-ras and N-ras oncogenes in primary renal mesenchymal tumors induced in F344 rats by methyl(methoxymethyl)nitrosamine.

S. Sukumar, A. Perantoni, C. Reed, J. M. Rice, M. L. Wenk

Research output: Contribution to journalArticlepeer-review

Abstract

Administration of methyl(methoxymethyl)nitrosamine to newborn Fischer 344 rats results in the preferential induction of renal tumors arising from the mesenchymal component of the kidney. DNA from a significant proportion of these tumors was capable of transforming NIH/3T3 cells. This report describes the renal tumor model, the detection of two different ras transforming genes in the kidney tumors (the N-ras oncogene in 1 and K-ras oncogene in 10 kidney tumors) and the characterization of DNA sequences specifying the transformed phenotype.

Original languageEnglish (US)
Pages (from-to)2716-2720
Number of pages5
JournalMolecular and cellular biology
Volume6
Issue number7
DOIs
StatePublished - Jul 1986

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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