Abstract
Recent genome-wide studies of malignancies of the central nervous system (CNS) have revolutionized our understanding of the biology of these tumors. This newly gained knowledge provides a wealth of opportunity for biomarker-driven clinical research. To date, however, only few of the available molecular markers truly influence clinical decision-making and treatment. The most widely validated markers in neuro-oncology presently are: (i) MGMT promoter methylation as a prognostic and predictive marker in glioblastoma; (ii) codeletion of 1p and 19q differentiating oligodendrogliomas from astrocytomas; (iii) IDH1/2 mutations; and (iv) select pathway-associated mutations. This article focuses on currently impactful biomarkers in adult and pediatric brain cancers and it provides a perspective on the direction of research in this field.
Original language | English (US) |
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Pages (from-to) | 338-349 |
Number of pages | 12 |
Journal | Trends in Cancer |
Volume | 2 |
Issue number | 7 |
DOIs | |
State | Published - Jul 1 2016 |
Keywords
- BRAF mutation
- IDH mutation
- biomarker
- codeletion MGMT promoter methylation
- codeletion of 1p/19q
- glioblastoma
- glioma
- medulloblastoma
ASJC Scopus subject areas
- Oncology
- Cancer Research