Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling

A. Cimponeriu, C. F. Starmer, A. Bezerianos

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

In order to identify generic mechanisms for altering the ECG during ischemia, we explored changes in the action potential propagation during different ischemic conditions using simple cellular models. Based on the Beeler-Reuter and Lou-Rudy I cellular models, we developed a ventricular tissue model for probing how alterations in shape and propagation of action potential distorted the theoretical ECG signal. If arrhythmias are a characteristic of acute ischemia, the changes in ST segment duration and T wave shape seems to be related with chronic ischemia and presence of the unexcitable medium. During different stages of ischemia, the changes in theoretical ECG indicated possibilities for detecting the relation between cellular changes and external measurement of the electrical activity of the heart.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
Pages317-320
Number of pages4
Volume0
Edition0
StatePublished - 1998
Externally publishedYes

Fingerprint

Electrocardiography
Action Potentials
Ischemia
Tissue
Bioelectric potentials
Cardiac Arrhythmias

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

Cite this

Cimponeriu, A., Starmer, C. F., & Bezerianos, A. (1998). Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling. In Computers in Cardiology (0 ed., Vol. 0, pp. 317-320)

Action potential propagation in ischemic cardiac tissue : A theoretical computer modeling. / Cimponeriu, A.; Starmer, C. F.; Bezerianos, A.

Computers in Cardiology. Vol. 0 0. ed. 1998. p. 317-320.

Research output: Chapter in Book/Report/Conference proceedingChapter

Cimponeriu, A, Starmer, CF & Bezerianos, A 1998, Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling. in Computers in Cardiology. 0 edn, vol. 0, pp. 317-320.
Cimponeriu A, Starmer CF, Bezerianos A. Action potential propagation in ischemic cardiac tissue: A theoretical computer modeling. In Computers in Cardiology. 0 ed. Vol. 0. 1998. p. 317-320
Cimponeriu, A. ; Starmer, C. F. ; Bezerianos, A. / Action potential propagation in ischemic cardiac tissue : A theoretical computer modeling. Computers in Cardiology. Vol. 0 0. ed. 1998. pp. 317-320
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