Action potential duration inhomogeneities in acute myocardial ischemia

A simulation study

J. M. Ferrero, B. Rodriguez, B. Trenor, V. Torres, J. Sáiz, J. M. Ferrero, Nitish V Thakor

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

It is well known that spatial heterogeneity in the distribution of action potential duration (APD) is one of the conditions that set the stage for cardiac arrhythmias. Alternons in the APD induced by myocardial ischemia is one of the mechanisms that may provoke this dispersion. As the genesis of these alternons is not well understood, the authors have used computer simulation to study this phenomenon. The Luo-Rudy model for the cardiac action potential (AP), completed with a formulation of the ATP-sensitive K+ current, was used to simulate ischemic APs. Under certain conditions, alternating APs that resembled those observed experimentally were obtained. Analysis of individual ionic concentrations, currents and gates suggested that small differences in intracellular Ca2+ concentrations in the onset of consecutive APs, together with a reduced cellular excitability, might be the cause of the electrical alternans.

Original languageEnglish (US)
Title of host publicationComputers in Cardiology
Pages577-580
Number of pages4
Volume0
Edition0
StatePublished - 1998

Fingerprint

Adenosinetriphosphate
Action Potentials
Myocardial Ischemia
Computer simulation
Computer Simulation
Cardiac Arrhythmias
Adenosine Triphosphate

ASJC Scopus subject areas

  • Software
  • Cardiology and Cardiovascular Medicine

Cite this

Ferrero, J. M., Rodriguez, B., Trenor, B., Torres, V., Sáiz, J., Ferrero, J. M., & Thakor, N. V. (1998). Action potential duration inhomogeneities in acute myocardial ischemia: A simulation study. In Computers in Cardiology (0 ed., Vol. 0, pp. 577-580)

Action potential duration inhomogeneities in acute myocardial ischemia : A simulation study. / Ferrero, J. M.; Rodriguez, B.; Trenor, B.; Torres, V.; Sáiz, J.; Ferrero, J. M.; Thakor, Nitish V.

Computers in Cardiology. Vol. 0 0. ed. 1998. p. 577-580.

Research output: Chapter in Book/Report/Conference proceedingChapter

Ferrero, JM, Rodriguez, B, Trenor, B, Torres, V, Sáiz, J, Ferrero, JM & Thakor, NV 1998, Action potential duration inhomogeneities in acute myocardial ischemia: A simulation study. in Computers in Cardiology. 0 edn, vol. 0, pp. 577-580.
Ferrero JM, Rodriguez B, Trenor B, Torres V, Sáiz J, Ferrero JM et al. Action potential duration inhomogeneities in acute myocardial ischemia: A simulation study. In Computers in Cardiology. 0 ed. Vol. 0. 1998. p. 577-580
Ferrero, J. M. ; Rodriguez, B. ; Trenor, B. ; Torres, V. ; Sáiz, J. ; Ferrero, J. M. ; Thakor, Nitish V. / Action potential duration inhomogeneities in acute myocardial ischemia : A simulation study. Computers in Cardiology. Vol. 0 0. ed. 1998. pp. 577-580
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