Actin R256 Mono-methylation Is a Conserved Post-translational Modification Involved in Transcription

Ashok Kumar, Yuan Zhong, Amelie Albrecht, Pau Biak Sang, Adrian Maples, Zhenan Liu, Vinesh Vinayachandran, Rohit Reja, Chia Fang Lee, Ashutosh Kumar, Jiyuan Chen, Jing Xiao, Bongsoo Park, Jianjun Shen, Bin Liu, Maria D. Person, Kathleen M. Trybus, Kam Y.J. Zhang, B. Franklin Pugh, Kristine E. KammDianna M. Milewicz, Xuetong Shen, Prabodh Kapoor

Research output: Contribution to journalArticlepeer-review

Abstract

Nuclear actin and actin PTMs are poorly understood. Kumar et al. discover a system of actin PTMs similar to histone PTMs, including a conserved mark on nuclear actin (R256me1) with potential implications for transcription and human diseases.

Original languageEnglish (US)
Article number108172
JournalCell Reports
Volume32
Issue number13
DOIs
StatePublished - Sep 29 2020

Keywords

  • INO80
  • PRMT5
  • TAAD
  • actin
  • actin PTMs
  • arginine monomethylation
  • nuclear actin
  • transcription

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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