Although microtubules are well-studied players moving chromosomes during mitosis and meiosis, recent work in mammalian oocytes has revealed intricate interactions between actin and chromosomes that directly control the positioning and extrusion of chromosomes during asymmetric meiotic cell divisions. New evidence also suggests that actin and actin-based motor proteins play interesting roles in the assembly and orientation of both meiotic and mitotic spindles. In this chapter we review what is known to date in this emerging area of actin-based motility and discuss outstanding questions and key mechanistic issues for future study.
|Original language||English (US)|
|Title of host publication||Actin-based Motility|
|Subtitle of host publication||Cellular, Molecular and Physical Aspects|
|Number of pages||21|
|State||Published - Jan 1 2010|
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